The singer who could be killed by a COOKIE

Fiona Cooper-Smyth, who lives in Perth, Australia, went into anaphylactic shock after accidentally eating a tiny amount of the legume lupin, commonly used in baked products, in a granola pot.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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IgE-mediated activation of mast cells is a hallmark of an anaphylactic reaction to allergen. In this issue of the JCI, Duan et al. describe an approach for suppressing IgE-dependent mast cell activation, thereby suppressing anaphylaxis. Specifically, the authors show that delivery of liposomes containing both the specific antigen recognized by the mast cell–bound IgE and a high-affinity glycan ligand of the inhibitory receptor CD33 (CD33L) to targeted mast cells inhibits antigen-induced, FcεRI-dependent spleen tyrosine kinase (Syk) phosphorylation and downstream protein tyrosine kinase (PTK) phosphorylation, ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Allergen immunotherapy for patients with allergies begins with weekly escalating doses of allergen under medical supervision to monitor and treat IgE mast cell–mediated anaphylaxis. There is currently no treatment to safely desensitize mast cells to enable robust allergen immunotherapy with therapeutic levels of allergen. Here, we demonstrated that liposomal nanoparticles bearing an allergen and a high-affinity glycan ligand of the inhibitory receptor CD33 profoundly suppressed IgE-mediated activation of mast cells, prevented anaphylaxis in Tg mice with mast cells expressing human CD33, and desensitized mice to subse...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Among all cystic echinococcosis cases, only 0.5%-2% exhibit a cardiac involvement. Only 10% of these become symptomatic. Considering the long time interval between the start of infestation and symptoms to occur, it is hard to diagnose cystic echinococcosis. When detected, even if it is asymptomatic, intramyocardial hydatid cyst requires surgical intervention due to risks of spontaneous rupture and anaphylaxis. In literature, no case of hydatid cyst located in the coronary arterial wall has been reported. Twenty-two-year-old male patient with previous history of pulmonary cystic echinococcosis was referred to us w...
Source: Brazilian Journal of Cardiovascular Surgery - Category: Cardiology Source Type: research
ConclusionAlthough the majority of ARs during OIT are non anaphylactic, AARs occur frequently. Children with higher sIgE for alpha-lactalbumine and casein at baseline seem to be at higher risk for AARs during OIT.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Conclusions: An observation time of ≥6 h after resolution of an initial anaphylaxis symptom can exclude recurrence of a secondary reaction in #x3e; 95% of patients. Although longer observation periods resulted in the detection of more biphasic reactions, 6–12 h of observation time would be practical, supporting current relevant gu idelines.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
(Natural News) Most allergies hit a person immediately after exposure: Symptoms are bound to develop immediately, from itchy hives to swelling, and even anaphylactic shock. The reactions can be dangerous and potentially fatal, but most of these can be identified and treated immediately. However, some people experience allergic reactions that seem to come out of...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Publication date: 2019Source: European Journal of Radiology Open, Volume 6Author(s): Kei Shibuya, Shu Kasama, Ryuichi Funada, Hiroyuki Katoh, Yoshito TsushimaAbstractKounis syndrome (KS) is an acute coronary disorder associated with anaphylactic reactions. The purpose of this report is to identify the features of KS triggered by contrast media on the basis of our experience and from literature review.We have described a case and literature review of KS triggered by injection of contrast media. Including the present case, we reviewed eleven cases of KS. Six cases developed KS in diagnostic radiology departments.KS could be ...
Source: European Journal of Radiology Open - Category: Radiology Source Type: research
Drugs are the most frequent cause of fatal anaphylaxis worldwide(1). The prevalence of adverse drug reactions (ADRs), including allergy, is known to be related to drug exposure frequency, gender, age, ethnicity and genetic factors, and it varies according to the classes of drugs, definitions of hypersensitivity reactions (HRs) and study design. Drug usage patterns vary significantly with time and geography, both across large countries and around the world(1-3).
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Source: Allergo Journal International - Category: Allergy & Immunology Source Type: research
CONCLUSION: While colloids are an uncommon cause of immediate hypersensitivity reactions, they can lead to severe and potentially fatal reactions if not recognized and treated promptly. PMID: 30758852 [PubMed - as supplied by publisher]
Source: Transfusion - Category: Hematology Authors: Tags: Transfusion Source Type: research
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