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Regulators Say Herbal Supplement Kratom Contains Opioids

WASHINGTON (AP) — U.S. health authorities say an herbal supplement promoted as an alternative pain remedy contains the same chemicals found in opioids, the addictive family of drugs at the center of a national addiction crisis. The Food and Drug Administration analysis, published Tuesday, makes it more likely that the supplement, kratom, could be banned by the federal government. The FDA also said it has identified 44 reports of death involving kratom since 2011, up from 36 reported in November. Sold in various capsules and powders, kratom has gained popularity in the U.S. as a treatment for pain, anxiety and drug dependence. Proponents argue that the substance is safer than opioid painkillers like OxyContin and Vicodin, which have contributed to an epidemic of drug abuse. More than 63,000 Americans died in 2016 from drug overdoses, mostly from opioids. FDA Commissioner Scott Gottlieb reiterated that there are no FDA-approved medical uses for kratom, which is derived from a plant native to Southeast Asia. "Claiming that kratom is benign because it's 'just a plant' is shortsighted and dangerous," Gottlieb said in a statement. "It's an opioid. And it's an opioid that's associated with novel risks because of the variability in how it's being formulated, sold and used recreationally." FDA scientists analyzed the 25 most common chemical compounds in kratom and concluded that they behave like those found in opioids including morphine. Kratom remains legal ...
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: Patient Care News Source Type: news

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Anorectal pain and discomfort are common complaints in the general population, and can stem from a number of possible causes. Often, the complaints present in the primary care setting and can be adequately evaluated, diagnosed, and treated without the need for referral to a colorectal specialist. Proper evaluation and diagnosis can result in prompt, effective patient care. Recognition of red flags should prompt immediate referral to a colorectal specialist for further evaluation.
Source: Journal of the American Academy of Physician Assistants - Category: Primary Care Tags: Review Article Source Type: research
CONCLUSIONS: ISRs have been reported with ixekizumab during clinical trials. These reactions are typically tolerable, manageable, and decrease over time. Clinicaltrials.gov: NCT01474512 (UNCOVER-1); NCT01597245 (UNCOVER-2); NCT01646177 (UNCOVER-3); NCT01777191 (UNCOVER-A); NCT01624233 (UNCOVER-J); NCT01107457 (I1F-MC-RHAJ); NCT02561806 (I1F-MC-RHBS); NCT02387801 (I1F-US-RHBO);NCT02513550 (I1F-MC-RHBP); NCT02634801 (I1F-EW-RHBZ) J Drugs Dermatol. 2018;17(2):200-206. THIS ARTICLE HAD BEEN MADE AVAILABLE FREE OF CHARGE. PLEASE SCROLL DOWN TO ACCESS THE FULL TEXT OF THIS ARTICLE WITHOUT LOGGING IN. NO PURCHASE NECESSARY. PLEAS...
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Authors: Harper J, Del Rosso JQ, Ferrusi IL Abstract Rosacea is a chronic skin condition characterized by persistent central facial erythema. To explore the burden of illness of rosacea in US adults, a cross-sectional web-based survey was conducted. Participants answered questions on sociodemographics, clinical characteristics, bothersome symptoms, coping and avoidance behaviors, self-perceptions, and health care resource utilization, and completed 2 quality of life instruments, the 21-item rosacea-specific quality of life questionnaire (RosaQoL) and the 36-item Short Form Health Survey (SF-36). This paper reports ...
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Conclusions: This study provides useful data to better understand the anatomical changes induced by OK in corneal SBNP. The different response observed to the 2 OK lens designs requires further investigation.
Source: Eye and Contact Lens: Science and Clinical Practice - Category: Opthalmology Tags: Article Source Type: research
Purpose: To compare tear film osmolarity (TFO) measurements in non–contact lens (CL) wearers and wearers of hydrogel or overnight orthokeratology (OK) CLs, and to assess possible effects of long-term OK on TFO. Methods: Overall, 108 subjects with moderate myopia participated in 2 experiments, and TFO was measured using the TearLab osmolarity system. In experiment 1, TFO measurements were made in 77 right eyes of 23 non-CL wearers, 26 hydrogel wearers, and 28 OK wearers. Subjects in the last 2 groups had worn their CL for at least 3 years. In experiment 2, 31 individuals (habitual soft CL wearers) were enrolled f...
Source: Eye and Contact Lens: Science and Clinical Practice - Category: Opthalmology Tags: Article Source Type: research
Purpose: To examine the effects of one year of overnight orthokeratology (OK) treatment on the sub-basal nerve plexus (SBNP) and corneal sensitivity and to assess the reversibility of these effects one month after treatment interruption. Methods: Thirty-two subjects with low-moderate myopia underwent OK treatment for one year. Fifteen non-contact lens wearers served as controls. At the time points baseline, one year of treatment, and one month after removing the OK lenses, two tests were conducted: corneal sensitivity (Cochet–Bonnet esthesiometer) and SBNP imaging by in vivo confocal microscopy. Results: In p...
Source: Eye and Contact Lens: Science and Clinical Practice - Category: Opthalmology Tags: Article Source Type: research
Conclusion: Most changes of mean aberrations were related to cyclopentolate drops. Tropicamide and artificial tears had the second and third rank according to their effect on mean errors. As a result, it seems that ocular accommodation is the most important impact on HOA than pupil size. However, the pupil size is the second factor for HOAs.
Source: Eye and Contact Lens: Science and Clinical Practice - Category: Opthalmology Tags: Article Source Type: research
Peripheral nervous system damage from hematologic malignancies is related to neoplastic cells infiltration of peripheral nerves or to monoclonal antibody production cross-reacting with peripheral nerves' antigens. Neurolymphomatosis (NL), a rare manifestation of hematologic malignancies, occurs when malignant cells invade the peripheral nerves leading to various manifestations. Here, we report a case of NL with 2 hematologic malignancies in a 79-year-old woman presenting with lower extremity pain/weakness. Investigation revealed anemia, IgM kappa monoclonal gammopathy, and elevated anti-MAG titer. Electrodiagnostic studies...
Source: Journal of Clinical Neuromuscular Disease - Category: Neurology Tags: Case Review Source Type: research
We report a 27-year-old woman with a history of adenoid cystic carcinoma of the submandibular gland presented with painful twitching of her left shoulder. Electrodiagnostic studies were consistent with a diagnosis of radiation-induced spinal accessory nerve hyperactivity. The patient failed conventional medical therapy. She was treated with an injection of botulinum toxin A, and within 1 month experienced significant relief of symptoms. We thus conclude that Botulinum toxin is a therapeutic option for the pain associated with radiation-induced peripheral nerve hyperactivity.
Source: Journal of Clinical Neuromuscular Disease - Category: Neurology Tags: Short Report Source Type: research
(WASHINGTON) — U.S. health authorities say an herbal supplement promoted as an alternative pain remedy contains the same chemicals found in opioids, the addictive family of drugs at the center of a national addiction crisis. The Food and Drug Administration analysis, published Tuesday, makes it more likely that the supplement, kratom, could be banned by the federal government. The FDA also said it has identified 44 reports of death involving kratom since 2011, up from 36 reported in November. Sold in various capsules and powders, kratom has gained popularity in the U.S. as a treatment for pain, anxiety and drug depen...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Addiction APH healthytime onetime Source Type: news
More News: Addiction | Anxiety | Chemistry | Complementary Medicine | Emergency Medicine | Epidemics | Epidemiology | Food and Drug Administration (FDA) | Government | Herbs | Hydrocodone | Legislation | Lortab | Morphine | Myopia (short sighted) | Overdose | Oxycodone | OxyContin | Pain | Politics | Substance Abuse | Vicodin