The impact of anaemia, transfusion dependency, comorbidities and polypharmacy in elderly patients with low-risk myelodysplastic syndromes

AbstractMyelodysplastic syndromes (MDS) are heterogeneous clonal disorders ranging from indolent conditions with a near-normal life expectancy to forms approaching acute myeloid leukaemia. Comorbid conditions have rarely been systematically studied among patients with MDS. Older age per se has a negative impact on survival of MDS patients, in particular of those with lower risk. However, age indirectly affects also the survival of higher-risk patients by limiting their eligibility to intensive treatments. In addition, ageing is associated with an increasingly high risk of developing comorbidity, and a high prevalence of comorbid diseases has indeed been reported in MDS patients. The impact of multi-morbidities/comorbidities and polypharmacy in patients with low-risk MDS patients is a poorly explored topic. We focused on medications, multi-morbidities and comorbidities of 155 low-risk MDS patients followed in the haematological outpatients clinics or in medical/oncology wards of our University Hospital. One or more comorbidities were present at diagnosis in 24 younger patients with MDS syndromes (31%), whereas 56 older patients with MDS (75%) presented 1 or more comorbidities (P 
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

Authors: Wu R, Yang H, Wan J, Deng X, Chen L, Hao S, Ma L Abstract Leukemia and lymphoma are common hematological malignancies in children and young adults, which pose a tremendous threat to the survival of these young patients worldwide, despite availability of various effective treatments. The Hippo pathway is a novel‑signaling pathway that regulates organ size, cell proliferation, apoptosis and tumorigenesis. The chief component of this pathway is the transducer yes‑associated protein (YAP) which is over‑expressed in numerous categories of tumors. However, little is known about the effect of YAP in hematol...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
In conclusion, miR‑339‑5p may serve its antiproliferative role in AML by directly targeting SOX4, which suggests that miR‑339‑5p may be considered an effective novel therapeutic target for treating patients with such an aggressive haematological malignancy. PMID: 30320397 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Authors: Azevedo AP, Silva SN, Reichert A, Lima F, Júnior E, Rueff J Abstract Several single nucleotide polymorphisms (SNPs) influencing DNA repair capacity and apoptotic status may confer genetic predisposition to Philadelphia‑chromosome negative myeloproliferative neoplasms (PN‑MPNs), and influence therapeutic response and the clinical course. In the present study, whether SNPs in genes involved in apoptosis and the base excision repair (BER) pathway was evaluated. In addition, some known risk factors in PN‑MPNs that may influence survival and therapeutic response to hydroxyurea (HU) were analyzed, t...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model. Mol Med Rep. 2018 Oct 03;: Authors: Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K Abstract PM2.5 is a particle with a diameter
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
CONCLUSION: The REVELA13 observatory has improved our epidemiological knowledge on female bladder tumors in Bouches-du-Rhône county and highlighted a local over incidence. LEVEL OF EVIDENCE: 3. PMID: 30316672 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
A new study explores the potential prognostic role of anemia in patients with pulmonary hypertension due to COPD.BMC Pulmonary Medicine
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news
Contributors : Liangxian Cao ; Marla Weetall ; Christopher Trotta ; Katherine Cintron ; Jiyuan Ma ; Min J Kim ; Bansri Furia ; Charles Romfo ; Jason D Graci ; Wencheng Li ; Joshua Du ; Josephine Sheedy ; Jean Hedrick ; Nicole Risher ; Shirley Yeh ; Hongyan Qi ; Tamil Arasu ; Seongwoo Hwang ; William Lennox ; Ronald Kong ; Janet Petruska ; Young-Choon Moon ; John Babiak ; Thomas W Davis ; Allan Jacobson ; Neil G Almstead ; Art Branstrom ; Joseph M Colacino ; Stuart W PeltzSeries Type : Expression profiling by arrayOrganism : Homo sapiensPTC299 was identified as an inhibitor of VEGFA mRNA translation in a phenotypic screen a...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Daniel M. Johnson, Gudrun Antoons
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Internal Medicine Journal,Volume 0, Issue ja, -Not available-.
Source: Internal Medicine Journal - Category: Internal Medicine Authors: Source Type: research
Conclusion: The presented score is a simple and early predictor of both short- and long-term outcomes and identifies patients who should undergo rapid volume expansion to counteract hemoconcentration, the spreading of microvascular thrombosis, and the consequent increased organ damage.What is Known:• In eHUS, hemoconcentration is associated with worse short- and long-term outcome.• A prognostic index to identify patients at higher risk for complications at presentation is not available.What is New:• We developed a simple and early prognostic index for eHUS outcome with the combination of Hb and sCr at onset,...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
More News: Acute Leukemia | Acute Myeloid Leukemia | Anemia | Cancer & Oncology | Cardiology | Congestive Heart Failure | Heart | Heart Failure | Hospitals | Leukemia | Myelodysplastic Syndrome | Statistics | Study