Leucine-Rich Repeat Kinase 2 Controls the Ca2+/Nuclear Factor of Activated T Cells/IL-2 Pathway during Aspergillus Non-Canonical Autophagy in Dendritic Cells

Alicia Yoke Wei Wong, Vasilis Oikonomou, Giuseppe Paolicelli, Antonella De Luca, Marilena Pariano, Jan Fric, Hock Soon Tay, Paola Ricciardi-Castagnoli, Teresa Zelante
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

In this study the simultaneous production of biosurfactants and lipases by Aspergillus niger in a submerged bioprocess was analyzed. Full Factorial Design (23) was conducted to assess the influence of the malt extract (g ·L-1; 25, 50, 75) and soybean oil concentrations (% v/v; 0.0, 1.25, 2.5) and agitation rates (rpm; 0.0, 100, 200) on biosurfactant and lipase production. Higher levels of the factors favored microbial growth, while their lower levels favored the production of biosurfactants and lipases. The variabl es were optimized through the response surface methodology and desirability functions, obtaining simul...
Source: Brazilian Journal of Chemical Engineering - Category: Chemistry Source Type: research
Abstract Catalase is a potentially useful biocatalyst in various industrial bioprocesses (textile industry, food processing, and pulp and paper) that require removal of hydrogen peroxide. This process can be achieved in such reactors even under isothermal conditions. However, it is usually connected with a long duration of the process or with spending a considerable amount of biocatalyst for a unit mass of the transformed substrate, which in turn leads to an increase in operating costs. They can be limited by applying the optimal temperature control, which requires the values of the thermodynamic parameters -the activation...
Source: Brazilian Journal of Chemical Engineering - Category: Chemistry Source Type: research
Publication date: Available online 19 January 2019Source: Journal of BiotechnologyAuthor(s): Mateusz Wojtusik, Priscilla Vergara, Juan C. Villar, Felix Garcia-Ochoa, Miguel LaderoAbstractThe stabilization effects on a novel commercial β-glucosidase preparation from Aspergillus fumigatus during saccharification of ethanol-water pretreated wheat straw were analysed in comparison to this enzyme stability during cellobiose hydrolysis. For this purpose, the kinetics of β-glucosidase residual activity during cellobiose hydrolysis from 40 till 70 °C were studied, resulting in the fitting of a first-order part...
Source: Journal of Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 18 January 2019Source: Journal of BiotechnologyAuthor(s): Li-Nian Cai, Sheng-Nan Xu, Tao Lu, Dong-Qiang Lin, Shan-Jing YaoAbstractThe hydrolysis step by β-glucosidase (BGL) is generally recognized as the major limiting step in cellulose degradation and the BGLs with prominent enzymatic properties are of great importance for efficient utilization of lignocellulosic biomass. In order to identify some salt-tolerant BGLs, two BGL genes were cloned from marine Aspergillus niger ZJUBE-1 genome. Then two bgl expression cassettes driven by gpdA promoter were respectively transformed into mar...
Source: Journal of Biotechnology - Category: Biotechnology Source Type: research
In this study, seven chitinases from different bacteria and fungi were produced, characterized and their biocontrol abilities against graminaceous stem borers Eldana saccharina, Chilo partellus and Sesamia calamistis were assessed. All chitinases were stable over broad ranges of pH and temperature, however, recombinant fungal chitinases were more acid-stable than the bacterial counterparts. Chitinases from the thermophilic filamentous fungi Thermomyces lanuginosus SSBP (Chit1) and from Bacillus licheniformis (Chit lic) caused 70% and 80% mortality, respectively, in second instar larvae of E. saccharina. Six of the sev...
Source: Journal of Bioscience and Bioengineering - Category: Biomedical Science Source Type: research
In this study, a natural antimicrobial cationic peptide of epsilon-poly-l-lysine (EPL) decorated ordered mesoporous silica (SBA-15) was facilely prepared for the efficient loading of antifungal itraconazole (ITZ) drugs. The characterized mesoporous SBA-15/EPL/ITZ composite exhibited remarkable antifungal performance against Aspergillus fumigatus as a model mold, which was attributed to synergistic antifungal activities of ITZ and EPL in the mesopores. Moreover, the in vitro release behaviors of ITZ in the composite nanoexcipients both in simulated gastric fluid and fasted state simulated intestinal fluid were studied. The ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Conclusion: Our results clearly indicate that ATF4 was involved in the host antifungal immune response to A. fumigatus keratitis; expression was found to be dependent on TLR4, LOX-1 expression, and MAPKs pathway. PMID: 30647960 [PubMed]
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
CONCLUSION: The outcomes of this study exhibit a light towards a new step of heavy metal bioremediation. PMID: 30648900 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Microbial Drug Resistance, Ahead of Print.
Source: Microbial Drug Resistance - Category: Microbiology Authors: Source Type: research
This study demonstrates the great potential of Y. lipolytica as an industrial platform for itaconic acid production. PMID: 30656392 [PubMed - as supplied by publisher]
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research
More News: Allergy & Immunology | Aspergillus