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Leucine-Rich Repeat Kinase 2 Controls the Ca2+/Nuclear Factor of Activated T Cells/IL-2 Pathway during Aspergillus Non-Canonical Autophagy in Dendritic Cells

Alicia Yoke Wei Wong, Vasilis Oikonomou, Giuseppe Paolicelli, Antonella De Luca, Marilena Pariano, Jan Fric, Hock Soon Tay, Paola Ricciardi-Castagnoli, Teresa Zelante
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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ConclusionAlthough the number of fungal species causing CNS mycosis is increasing, only some possess well-defined treatment standards (e.g., cryptococcal meningitis and CNS aspergillosis). The early diagnosis of fungal infection, accompanied by identification of the etiological factor, is needed to allow the selection of effective therapy in patients with FIs-CNS and limit their high mortality.
Source: Infection - Category: Infectious Diseases Source Type: research
Publication date: October 2018 Source:Protein Expression and Purification, Volume 150 Author(s): Aline Vianna Bernardi, Paula Fagundes de Gouvêa, Luis Eduardo Gerolamo, Deborah Kimie Yonamine, Laís de Lourdes de Lima Balico, Sergio Akira Uyemura, Taisa Magnani Dinamarco A gene encoding an endo-1,4-β-glucanase (Afu6g01800) from A. fumigatus was cloned into the vector pET-28a(+) and expressed in the E. coli strain RosettaTM (DE3) pLysS. Sequence analysis indicated that the enzyme Af-EGL7 belonged to the GH7 family. The gene Af-egl7 encoded a protein comprising 460 amino acids, with a CBM1 domain at residue...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
r Ulrike Binder Mucorales are fungi with increasing importance in the clinics. Infections take a rapidly progressive course resulting in high mortality rates. The ergosterol biosynthesis pathway and sterol composition are of interest, since they are targeted by currently applied antifungal drugs. Nevertheless, Mucorales often exhibit resistance to these drugs, resulting in therapeutic failure. Here, sterol patterns of six clinically relevant Mucorales (Lichtheimia corymbifera, Lichtheimia ramosa, Mucor circinelloides, Rhizomucor pusillus, Rhizopus arrhizus, and Rhizopus microsporus) were analysed in a targeted metabo...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Mao Peng, Maria V. Aguilar-Pontes, Ronald P. de Vries, Miia R. M äkelä
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.8b01841
Source: Journal of Agricultural and Food Chemistry - Category: Food Science Authors: Source Type: research
Publication date: Available online 18 May 2018 Source:Current Opinion in Food Science Author(s): Marta Hiromi Taniwaki, John I. Pitt, Naresh Magan Aspergillus species produce important mycotoxins, in particular aflatoxins, produced by A. flavus and related species, and ochratoxin A, produced by A. ochraceus and related species and also A. carbonarius and (less commonly) A. niger. In this review we briefly discuss the distribution of toxigenic Aspergillus species in nuts, coffee and cocoa beans, dried fruits, grapes, maize, rice and small grains. Future perspectives of distribution of Aspergillus species in foods is briefl...
Source: Current Opinion in Food Science - Category: Food Science Source Type: research
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Nantiya Bunbamrung, Chakapong Intaraudom, Aibrohim Dramae, Nattawut Boonyuen, Rungtiwa Chanthaket, Pranee Rachtawee, Pattama Pittayakhajonwut Four previously undescribed compounds, including (Z)-chloromonilinic acid B (1), (E)-chloromonilinic acid C (2), 4-chlorocurvularin (5), and 4-chlorocurvularinic acid (6), together with four known compounds, (E)-chloromonilinic acids A and B, pinselin, and anhydromevalonolactone, were isolated from the fungus Curvularia sp. BCC52426. The chemical structures were determined by comparing their NMR spectr...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
Conclusion The existence of triazole resistance among A. fumigatus isolates in Taiwan and mainland China indicates the need for continuous monitoring from now on.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Jun Yuan, Zhong Chen, Zhiqiang Guo, Ding Li, Feng Zhang, Jiaojiao Shen, Yi Zhang, Shihua Wang, Zhenhong Zhuang
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
This study investigated volatile and nonvolatile metabolite profiles of makgeolli (a traditional rice wine in Korea) fermented by koji inoculated with Saccharomycopsis fibuligera and/or Aspergillus oryzae. The enzyme activities in koji were also examined to determine their effects on the formation of metabolites. The contents of all 18 amino acids detected were the highest in makgeolli fermented by S. fibuligera CN2601-09, and increased after combining with A. oryzae CN1102-08, unlike the contents of most fatty acids. On the other hand, major volatile metabolites were fusel alcohols, acetate esters, and ethyl esters. The c...
Source: Food Research International - Category: Food Science Source Type: research
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