Supporting nurse mentors to reduce the barriers to implementing alcohol Interventions and Brief Advice (IBA) in primary care
Conclusion This project indicates that by supporting nurse mentors in leading on the implementation of IBA there is potential for reducing alcohol-related harm within the existing resources of the surgery. This could support primary care in the practical implementation of an evidence based cost effective intervention which has experienced patchy uptake. References 1 Her Majesty’s Government (2012) The Government’s Alcohol Strategy -2012 2 House of Commons Health Committee, 29012, Government’s Alcohol Strategy 3 National Institute for Health and Care Excellence (2012) Alcohol-use disorders: prevention Guideline PH24 4 Thom B. et al (2014) Delivering alcohol IBA: broadening the base from health to non-health contexts Alcohol insight number 116 Alcohol Research UK 5 PHE Alcohol Learning Resources 6 Event hosted jointly by the Royal College of GPs Foundation, the Committee of General Practice Education Directors (COGPED) and Health 6 6Education Wessex (HEW) November 2013 Nursing in Primary Care – ‘a roadmap to excellence’
A routine of light or moderate alcohol consumption ( ≤1 drink/day for women and 1 to 2 drinks/day for men) were associated with a lower risk for all-cause mortality, coronary artery disease (CAD), type 2 diabetes mellitus (T2D), heart failure (HF), and stroke. Conversely, heavy drinking, (>4 drinks/day) is associated with an increased risk for death and cardiovascular (CV) disease (CVD). Excessive alcohol intake trails behind only smoking and obesity among the 3 leading causes of premature deaths in the United States (US).
Excessive amounts of alcohol intake can damage many organs or deaths in severe cases. Heavy alcohol intake is also known to cause gut leakiness, contributing to increased endotoxemia and inflammatory tissue damage in the liver and brain [1 –4]. Various pathological conditions, such as HIV infection [5–7], obesity , and burn injury , are known to increase gut leakiness and endotoxemia. In addition, binge alcohol  and nonalcoholic substances such as high fat diets  and fructose  can stimulate gut leakiness, leading to elevated serum endotoxin and liver inflammation.
Contributors : Adil Mardinoglu ; Sunjae LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe performed a short-term dietary intervention with a low-carbohydrate diet in obese subjects with NAFLD
Background and ObjectiveSalivary lactate dehydrogenase (LDH) was reported to be a useful parameter for the screening of periodontal disease. We performed a cross‐sectional study to verify the usefulness of salivary LDH as a biomarker of periodontitis and to investigate the association of severity of periodontitis with systemic inflammation by measuring salivary LDH and serum high sensitive C‐reactive protein (hs‐CRP) levels in a community‐based middle‐aged and elderly population in Japan. Material and MethodsWe recruited 644 men and 1171 women, aged 30‐79 years, who participated in the Toon Health Study du...
Conclusion. Adult patients undergoing anterior lumbar interbody fusion who were morbidly obese and had history of alcohol use are at increased risk for 30-day readmissions. Future studies should look to directly compare readmission rates and risk factors between alternative lumbar interbody surgical approaches with longer follow-up and more clinical and radiological parameters investigated. Level of Evidence: 3
Conclusion The major lifestyle factors discussed in the present review are amongst the multiple potential risk factors that could impair male fertility. However, their negative impact may well be mostly overcome by behaviour modification and better lifestyle choices. Greater awareness and recognition of the possible impact of these lifestyle factors are important amongst couples seeking conception.
People looking to lose weight might try all kinds of ways to eat fewer calories. Now, a study in BMJ Open sheds some light onto which of those strategies actually work: Based on data from nearly 60,000 people, three behaviors—eating slowly, cutting out after-dinner snacks and not eating within two hours of going to bed—were linked to lower obesity rates and smaller waistlines. The study looked specifically at people in Japan with type 2 diabetes who had one to three health check-ups between 2008 and 2013. During those appointments, people were asked about their eating and sleeping habits, including how fast the...
ConclusionThis analysis combining data from two health systems shows that area deprivation is an independent risk factor for cognitive dysfunction in older adults. Adults living in areas of greatest socioeconomic deprivation may benefit from targeted strategies aimed at improving modifiable risk factors for dementia. Further cross‐national analysis investigating the impact of area‐level deprivation is needed to address socioeconomic disparities and shape future policy to improve health outcomes in older adults.
Low molecular weight fucoidan attenuates liver injury via SIRT1/AMPK/PGC1α axis in db/db mice. Int J Biol Macromol. 2018 Feb 12;: Authors: Zheng Y, Liu T, Wang Z, Xu Y, Zhang Q, Luo D Abstract Non-alcoholic fatty-liver disease (NAFLD), caused by elevated hepatic lipids, inflammation and oxidative stress, is the most common liver disease globally. Low molecular weight fucoidan (LMWF), a sulfated polysaccharide extracted from brown seaweeds, has shown strong anti-inflammatory and antioxidant activities, which has not been explored in diabetes-induced NAFLD. Therefore, the present study sought to d...
We report on a girl affected by epileptic seizures treated with levetiracetam for five years. Due to a worsening of the seizures, the dosage of this drug was increased and afterwards low-dosage topiramate was initiated. After 12 days from the introduction of topiramate, the girl began to present neurologic signs including limbs rigidity, pain, incoordination and flexed fingers. Gradual withdrawn of the topiramate resulted in a progressive resolution of the symptomatology. This clinical episode could represent a topiramate-related side effect, never reported before in this form. PMID: 29437013 [PubMed - as supplied by publisher]