Evidence Corner: Taking Itch Seriously.
Evidence Corner: Taking Itch Seriously. Wounds. 2018 Jan;30(1):27-28 Authors: Bolton LT Abstract Dear Readers, Itching (pruritus) of a wound, scar, or dermatologic disorder can negatively impact a patient's quality of life, resulting in injurious scratching1 or impeded rehabilitation.2 Like pain, itch can cause the su erer to lose sleep and appetite or even consider suicide.3,4 Clinical measures of pruritus have proved reliable and valid in individuals with burn wounds, dermatologic conditions, or urticaria5-7 or resulting scars,2 allowing studies to clarify its impact on human experience and compare the e ects of interventions to reduce itching. This Evidence Corner explores the e ects on pruritus of interventions applied at 2 very different stages of wound healing: the rst during early healing stages after hemorrhoidectomy8 and the other in postburn hypertrophic scarring with contracture.9 Each condition generates distressing levels of pruritus from which patients eagerly seek relief. PMID: 29406294 [PubMed - in process]
Publication date: Available online 19 November 2018Source: Brain, Behavior, and ImmunityAuthor(s): Sarah A. Woller, Cody Ocheltree, Stephanie Y. Wong, Anthony Bui, Yuya Fujita, Gilson Gonçalves dos Santos, Tony L. Yaksh, Maripat CorrAbstractIn rheumatoid arthritis, joint pain can persist despite resolution of swelling. Similarly, in the murine K/BxN serum transfer model, a persistent tactile allodynia is observed after the resolution of joint inflammation (post-inflammatory pain) in male mice. Here, we found female wild type (WT) mice show inflammatory, but reduced post-inflammatory tactile allodynia. The transition...
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Hongye Liu, Lei Ding, Huifeng Zhang, David Mellor, Haiyan Wu, Dongmei Zhao, Chuangxin Wu, Zhiguang Lin, Jiaojian Yuan, Daihui Peng
Rebecca McKetin, Alexandra Voce, Richard Burns, Robert Ali, Dan I. Lubman, Amanda L. Baker, David J. Castle
Anja Schaich, Laura Heikaus, Nele Assmann, Sandra K öhne, Kamila Jauch-Chara, Michael Hüppe, Adrian Wells, Ulrich Schweiger, Jan Philipp Klein, Eva Fassbinder
Conclusion: The stimulation of expression and function of Orai1/STIM1/2 by lithium in ChAc neurons are disrupted by pharmacological NF κB inhibition.Cell Physiol Biochem 2018;51:278 –289
CONCLUSION: A simple objective decision rule (CORE) identified one-third of all patients as having a very low 30-day risk of MACE. These patients may potentially be discharged without additional investigations for acute coronary syndrome. PMID: 30444442 [PubMed - as supplied by publisher]
Conclusions: Routine use of capsule endoscopy in patients with irritable bowel syndrome should not be recommended. However, in patients with refractory conditions, capsule endoscopy may identify abnormalities. PMID: 30441888 [PubMed - as supplied by publisher]