Serum levels of interleukin 6 in schizophrenic patients during treatment augmentation with sarcosine (results of the PULSAR study)

ConclusionsSarcosine does not significantly affect IL‐6 concentrations but IL‐6 may be involved in mechanisms related to the presence of positive symptoms.
Source: Human Psychopharmacology: Clinical and Experimental - Category: Psychiatry Authors: Tags: RESEARCH ARTICLE Source Type: research

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Over this past weekend, I participated in my first outreach event for Mental Health America at the NBC4 Telemundo 44 Health and Fitness Expo in Washington, D.C.  Dr. Martin Luther King said that people “fear each other because they do not know each other.  They do not know each other because they do not communicate with each other.”  Here is what I learned at the event: it is easy to communicate with people about mental health because the topic is accessible across culture, race and age. In addition, talking about mental health is especially important to those with mental illness. We had a s...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Communication Conferences General Mental Health America Mental Health and Wellness Policy and Advocacy Publishers connection Mental Health Advocacy Mental Health Policy Source Type: blogs
  Do you struggle with anger? Did you know that some of our most hot-headed moments are actually rooted in anxiety? In today’s podcast, Jackie openly shares her own fuse-blowing moment when her husband’s keys were (gasp!) missing from the hook, and now she must face being late for therapy and perhaps even lie dying on the side of the road. How did she handle this catastrophic situation her mind so graciously forewarned her about? Does this sound familiar? Join us as we discuss anxiety-driven anger and explore ways to minimize and possibly even prevent it. (Transcript Available Below) SUBSCRIBE &REVIEW...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anger Anxiety and Panic Disorders General Not Crazy Podcast Psychology Source Type: blogs
Authors: Kolomeets NS, Uranova NA Abstract There is increasing evidence to support the notion that oligodendrocyte and myelin abnormalities may contribute to the functional dysconnectivity found in the major psychiatric disorders. The putamen, which is an important hub in the cortico-striato-thalamo-cortical loop, has been implicated in a broad spectrum of psychiatric illnesses and is a central target of their treatments. Previously we reported a reduction in the numerical density of oligodendrocytes and oligodendrocyte clusters in the prefrontal and parietal cortex in schizophrenia. Oligodendrocyte clusters contai...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Conclusions: Certain modifiable risk factors play an inescapable role in increasing the level of burden among caregivers of older patients with serious mental illnesses.Clinical Implications: Improving the quality of life and psychological well-being of family caregivers should be considered an integral part of treatment for serious mental illness in older adult patients. PMID: 32058858 [PubMed - as supplied by publisher]
Source: Clinical Gerontologist - Category: Geriatrics Tags: Clin Gerontol Source Type: research
AbstractThere is increasing evidence from genetic, biochemical, pharmacological, neuroimaging and post-mortem studies that immunological dysregulation plays a crucial role in the pathogenesis of psychoses. The involvement of microglia in schizophrenia and bipolar disorder (BD) has remained controversial, however, since results from various post-mortem studies are still inconclusive. Here, we analyzed the estimated density of microglia of age-matched individuals with schizophrenia (n = 17), BD (n = 13), and non-psychiatric control subjects (n = 17) in the anterior midcingulate corte...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
Our weekly round-up of the best psychology coverage from elsewhere on the web A study on bearded dragons has honed in on the brain structure responsible for generating slow wave sleep patterns, writes Elizabeth Pennisi at Science. An area of the brain called the claustrum — not previously known to even exist in reptiles — was key: when the structure was damaged, the lizards could still sleep but showed no slow wave patterns. It’s been an interesting few months for bearded dragon research: as we wrote in December, the lizards apparently also succumb to optical illusions. A mismatch between a student&rsqu...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Weekly links Source Type: blogs
Authors: Ciafrè S, Ferraguti G, Tirassa P, Iannitelli A, Ralli M, Greco A, Chaldakov GN, Rosso P, Fico E, Messina MP, Carito V, Tarani L, Ceccanti M, Fiore M Abstract The nerve growth factor (NGF) belongs to a family of proteins named neurotrophins, consisting of NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5 and NT-6. NGF regulates a large number of physiological mechanisms that result in neurotrophic, metabotrophic and/or immunotrophic effects. Neurodegenerative diseases, including Alzheimer disease, psychiatric disorders (e.g. depression and schizophrenia) and brain parasitic...
Source: Rivista di Psichiatria - Category: Psychiatry Tags: Riv Psichiatr Source Type: research
This article summarizes the milestones in the development of lumateperone leading to this first approval for the treatment of schizophrenia.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
AbstractThere is increasing evidence to support the notion that oligodendrocyte and myelin abnormalities may contribute to the functional dysconnectivity found in the major psychiatric disorders. The putamen, which is an important hub in the cortico –striato–thalamo–cortical loop, has been implicated in a broad spectrum of psychiatric illnesses and is a central target of their treatments. Previously we reported a reduction in the numerical density of oligodendrocytes and oligodendrocyte clusters in the prefrontal and parietal cortex in sc hizophrenia. Oligodendrocyte clusters contain oligodendrocyte proge...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
Does the new coronavirus from China make you a little anxious? How concerned should we be? Is it a real threat or mostly hype? In today’s podcast, Dr. John Grohol, founder and editor-in-chief of PsychCentral.com, explains what the coronavirus is, how it compares to the flu and why it seems to have hit the panic button in a lot of people. He offers tips to avoid getting sick in general, and importantly, gives advice on how to keep our anxiety levels in check when it comes to new disease outbreaks, especially in how we seek information from the media. If you’d like to learn more about the coronavirus and how to...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic Disorders General Health-related Interview Podcast The Psych Central Show Source Type: blogs
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