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60-Year-Old Drug May Hold Clues To Stopping Spread Of Breast Cancer

One of the oldest chemotherapy drugs in the world may be able to stop breast cancer spreading, according to a new study.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news

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Authors: Pan T, Mao T, Yang H, Wang H, Wang Y Abstract The present study was designed to explore the sensitivity of MDA-MB-231 cells to cisplatin after silencing the expression of TG-interacting factor (TGIF) protein. Cell viability was measured using an MTT assay. Cell apoptosis was detected by the annexin V and dead cell assay and the Hoechst staining assay. Protein expression was analyzed using western blot analysis. A colony formation assay was also performed. It was observed that cisplatin reduced the expression of TGIF protein in a dose- and time-dependent manner. Silencing TGIF significantly suppressed the c...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Conclusion: Providing patients with strategies to further control nausea (p.r.n. antiemetics) in addition to guideline-consistent antiemetics is recommended for practice. Because the nausea experience contributes to symptom incidence in the next phase and cycle and because the nausea intensity demonstrated a significant relationship with function and global health/QOL, proactive supportive approaches are strongly recommended. Implications for Practice: Delayed nausea control may be improved by adhering to guideline-consistent antiemetics and using p.r.n. antiemetics. Delayed nausea control would contribute to patients...
Source: Cancer Nursing - Category: Nursing Tags: Articles: Online Only Source Type: research
ConclusionAlthough the study was terminated owing to the altered liver function, it showed that there was a trend to greater shrinkage of tumor in the combination group for ER-positive, HER2-negative postmenopausal breast cancer.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
ConclusionThese findings reveal for the first time that hydroxytyrosol is an active partner in combined therapies with paclitaxel against breast cancer. Combination with hydroxytyrosol would also ensure a less oxidative impact of chemotherapeutic drugs that could potentially improve patient wellness.
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent adverse reaction caused by chemotherapeutic agents, especially the taxanes. CIPN can persist from months to years after completion of chemotherapy, decreasing quality of life for cancer survivors. The aim of this study was to explore the incidence and risk factors of persistent CIPN among women with breast cancer receiving neoadjuvant chemotherapy.
Source: Journal of Psychosomatic Research - Category: Psychiatry & Psychology Authors: Source Type: research
The addition of metronomic chemotherapy to dual HER2 blockade improved outcomes in older and frail patients with HER2-positive metastatic breast cancer.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Tags: Breast Cancer HER2-Positive Breast Cancer News Source Type: news
This article presents a snapshot of my experience of being a nurse who became a service user with breast cancer. It begins by outlining the Humanization of Healthcare Framework ( Todres et al, 2009 ), which is a values-based context that can be used to underpin daily care. Generic applications for each of the dimensions of the framework are suggested. This framework is then used to contextualise my experience of receiving my diagnosis and the ensuing chemotherapy. Using examples from my personal narrative, I make some recommendations for 'small actions' that can contribute to more humanised and person-centred care. I also ...
Source: British Journal of Nursing - Category: Nursing Authors: Tags: Br J Nurs Source Type: research
Abstract Nurses are in a unique position to provide nutritional advice and information to women with breast cancer who are undergoing chemotherapy, supporting them with making decisions regarding nutrition and diet. This narrative review evaluated the research evidence relating to the nutritional challenges experienced during chemotherapy and the most effective approaches for supporting women in dietary choice. Weight gain was identified as a specific problem for women undergoing chemotherapy. The evidence indicated that information about nutrition and food preparation support may go some way in assisting women to...
Source: British Journal of Nursing - Category: Nursing Authors: Tags: Br J Nurs Source Type: research
In conclusion, it was identified that miR-96 exhibited an increased level in serum samples of patients with malignant breast cancer in comparison with benign breast tumor types and health controls and may be substantially reduced by chemotherapy treatment, implying that it may be used as a prognostic marker in breast cancer. miR-96 overexpression may inhibit migration of breast cancer cells by downregulating MTSS1 expression. PMID: 29456723 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Estrogen receptor-α promoter methylation is a biomarker for outcome prediction of cisplatin resistance in triple-negative breast cancer. Oncol Lett. 2018 Mar;15(3):2855-2862 Authors: Xu J, Sun T, Guo X, Wang Y, Jing M Abstract A number of previous studies have indicated the presence of a link between estrogen receptor-α (ERα) methylation and triple-negative breast cancer (TNBC). However, the association between ERα methylation and drug resistance during the treatment of TNBC remains unclear. Methylation-specific polymerase chain reaction was used to investigate the methylation o...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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