Modulation of human corticospinal excitability by paired associative stimulation in patients with amyotrophic lateral sclerosis and effects of Riluzole

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes an impairment in both the upper and lower motor neurons. The recent description of numerous non-motor signs points to an involvement of the neocortex networks that is more complex than was previously believed. Paired associative stimulation (PAS), a combination of transcranial magnetic stimulation (TMS) and peripheral nerve stimulation, can enhance motor output in the contralateral hand through an NMDA-mediated sensorimotor mechanism.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 7, 2018 Category: Neurology Authors: M. Ceccanti, E. Onesti, A. Rubino, C. Cambieri, G. Tartaglia, A. Miscioscia, V. Frasca, M. Inghilleri Source Type: research