Pharmacokinetic and Pharmacodynamic Markers of Mycophenolic Acid Associated with Effective Prophylaxis for Acute Graft-Versus-Host Disease and Neutrophil Engraftment in Cord Blood Transplant Patients
• Higher MPA acyl glucuronide concentrations were related with aGVHD of the GI tract.• Free MPA concentrations were associated with faster neutrophil engraftment.• Therapeutic range was suggested as free MPA AUC0-24 of 0.405–0.689 µg⋅h⋅mL−1.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Kazuaki Yoshimura, Ikuko Yano, Takashi Yamamoto, Tadakazu Kondo, Misaki Kawanishi, Yui Isomoto, Atsushi Yonezawa, Akifumi Takaori-Kondo, Kazuo Matsubara Source Type: research