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High Detection Rates of High - Grade DCIS Persist

Low - , intermediate - grade DCIS less frequently ID'd in subsequent screening rounds vs. prevalence round
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Gynecology, Oncology, Pathology, Radiology, Journal, Source Type: news

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Tumor-infiltrating lymphocytes and ductal carcinoma in situ of the breast: friends or foes?, Published online: 20 February 2018; doi:10.1038/s41379-018-0030-xTumor-infiltrating lymphocytes and ductal carcinoma in situ of the breast: friends or foes?
Source: Modern Pathology - Category: Pathology Authors: Source Type: research
CONCLUSION: These results could justify the conservative management, in a selected group of patients, being the malignancy rate lower than 2%, considered in the literature as the "probably benign" definition. Advances in knowledge: Increasing the length of follow-up of selected patients conservatively managed can improve the management of ADH cases. PMID: 29451396 [PubMed - as supplied by publisher]
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
Authors: Kim S, Lee S, Kim S, Lee S, Yum H Abstract Purpose: PET/CT is useful in preoperative evaluation of invasive breast cancer (IBC) to predict axillary metastasis and staging workup. The usefulness is unclear in cases of ductal carcinoma in situ (DCIS) diagnosed at biopsy before surgery, which sometimes is upgraded to IBC after definitive surgery. The aim of this study is to find out the usefulness of PET/CT on DCIS as a preoperative evaluation tool. Methods: We investigated 102 patients preoperatively diagnosed with DCIS who subsequently underwent definitive surgery between 2010 and 2015. The uptake of 18...
Source: Annals of Surgical Treatment and Research - Category: Surgery Tags: Ann Surg Treat Res Source Type: research
ConclusionsIn the SEER database, we observed far more deaths from DCIS than would be expected under a model where all deaths from breast cancer occur amongst women who experience an invasive local recurrence. This lends support to the hypothesis that DCIS mortality is not restricted to those women who experience an in-breast invasive cancer and that DCIS has properties similar to small invasive breast cancers.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Despite the significant biological, behavioural and management differences between ductal carcinoma in situ (DCIS) and invasive carcinoma of the breast, they share many morphological and molecular similarities. Differentiation of these two different lesions in breast pathological diagnosis is based typically on the presence of an intact barrier between the malignant epithelial cells and stroma; namely, the myoepithelial cell (MEC) layer and surrounding basement membrane (BM). Despite being robust diagnostic criteria, the identification of MECs and BM to differentiate in‐situ from invasive carcinoma is not always straight...
Source: Histopathology - Category: Pathology Authors: Tags: Review Source Type: research
CONCLUSIONS: - Rare, invasive, primary nipple carcinomas typically present as subtle nipple thickening or an exudative crust on the skin. Imaging studies are often nonrevealing. A variety of histologic and biologic types of carcinomas occur, similar to cancers arising deeper in the breast. Although the carcinomas invaded into the dermis, some with skin ulceration, the likelihood of lymph node metastasis was no higher than carcinomas of similar sizes. Patients who choose to preserve their nipple(s) should be aware of the possibility of breast cancer arising at that site and to bring any observed changes to the attention of ...
Source: Archives of Pathology and Laboratory Medicine - Category: Laboratory Medicine Authors: Tags: Arch Pathol Lab Med Source Type: research
ConclusionPatients that achieved a pCR appeared less likely to present with skeletal metastases and more frequently presented with CNS metastases as first site of distant relapse, even after adjustment for molecular subtypes.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
The objective of the present study was to evaluate the effectiveness of postoperative radiotherapy after breast conserving surgery (BCS) in DCIS in a large patient population treated in clinical practice.
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Yasser Khouj, Jeremy Dawson, James Coad, Linda Vona-Davis
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsOur results demonstrate that maintaining healthy behaviors following DCIS treatment is associated with modest improvements in long-term QoL. These results inform interventions aimed at promoting healthy behaviors and optimizing QoL in DCIS survivors.
Source: Quality of Life Research - Category: Health Management Source Type: research
More News: Cancer & Oncology | DCIS (Ductal Carcinoma in Situ) | Ductal Carcinoma | Pathology | Radiology