High Detection Rates of High - Grade DCIS Persist
Low - , intermediate - grade DCIS less frequently ID'd in subsequent screening rounds vs. prevalence round
Condition: DCIS Intervention: Drug: Palbociclib Sponsors: Georgetown University; Pfizer Not yet recruiting
g Xin Liu Many previous works only focused on the cascading failure of global coupling of one-to-one structures in interdependent networks, but the local coupling of dual coupling structures has rarely been studied due to its complex structure. This will result in a serious consequence that many conclusions of the one-to-one structure may be incorrect in the dual coupling network and do not apply to the smart grid. Therefore, it is very necessary to subdivide the dual coupling link into a top-down coupling link and a bottom-up coupling link in order to study their influence on network robustness by combining with dif...
CONCLUSIONS: Routinely performing SLN biopsy for patients undergoing mastectomy for a preoperative diagnosis of DCIS is overtreatment, because the prevalence of SLN metastasis was low. SLN biopsy can be omitted for most patients. In particular, we suggest omitting SLN biopsy for patients who have lesions of ultrasound category 0-3, who have neither a mass nor NMA detected by ultrasound, or whose initial diagnosis was made based on a specimen obtained by methods other than CNB. PMID: 29786772 [PubMed - as supplied by publisher]
SummaryThis year there were three interesting oral presentations and several posters presenting important new data regarding local therapy (surgery and radiotherapy) as well as radiological aspects. This minireview is a personal view of the clinically most relevant data in this respect with the following conclusions: A micrometastasis is no indication for axillary dissection. The number of involved sentinel lymph nodes predicts non-sentinel lymph node metastasis and should be taken into account regarding omittin g axillary dissection. Neoadjuvant chemotherapy reduces the risk of non-sentinel lymph node metastasi...
No abstract available
Morphological variants of lobular carcinoma in situ (LCIS) include classical- (CLCIS), pleomorphic- (PLCIS) and florid-type (FLCIS). Treatment guidelines suggest managing PLCIS and FLCIS like ductal carcinoma in situ (DCIS); therefore accurate identification of LCIS subtypes is critical. However significance of separating PLCIS from FLCIS is not clear. Also inter-observer agreement in identifying LCIS subtypes, using contemporary criteria, is not known. We aimed to evaluate inter-observer agreement amongst breast pathologists in diagnosing LCIS subtypes and use the agreement data to justify LCIS classification for management purposes.
Regular breast cancer screening, particularly in younger women, translates...Read more on AuntMinnie.comRelated Reading: ASBrS: No, we're not overtreating DCIS ASBrS: 50% of women under 45 at elevated breast cancer risk ASBrS: For node-positive breast cancer, radiotherapy is best ASBrS: Radiotherapy after mastectomy may not be beneficial ASBrS: RF ablation shows promise; thermography not so much
ConclusionsThe risk of IHD was lower for women with DCIS allocated to RT compared to non-irradiated women and to the comparison cohort, probably due to patient selection. Comparison of RT by laterality did not show any over-risk for irradiation of the left breast.
Ductal carcinoma in situ is presumably not a metastatic disease: a reply to "Commentary: Wherein the authors attempt to minimize the confusion generated by their study 'Breast cancer mortality after a diagnosis of ductal carcinoma in situ' by several commentators who disagree with them and a few who don't: a qualitative study". Curr Oncol. 2018 Apr;25(2):e183 Authors: Snodgrass BT PMID: 29719444 [PubMed - in process]
Authors: Chaudhry AT, Koulis TA, Speers C, Olson RA Abstract Purpose: The mainstay of treatment for ductal carcinoma in situ (dcis) involves surgery in the form of mastectomy or lumpectomy. Inconsistency in the use of endocrine therapy (et) for dcis is evident worldwide. We sought to assess the variation in et prescribing for patients with dcis across a population-based radiotherapy (rt) program and to identify variables that predict its use. Methods: Data from a breast cancer database were obtained for women diagnosed with dcis in British Columbia from 2009 to 2014. Associations between et use and patient char...