UPMC researchers solving treatment resistance in most common breast cancer
(University of Pittsburgh Schools of the Health Sciences) For the first time researchers have identified recurrent ESR1 fusion proteins in human breast cancer, to understand how they function and help lead to improved treatments for the disease.
Publication date: 1 December 2018Source: Sensors and Actuators B: Chemical, Volume 275Author(s): Girija Gaur, Shuren Hu, Raymond L. Mernaugh, Ivan I. Kravchenko, Scott T. Retterer, Sharon M. WeissAbstractHighly sensitive detection of heat denatured Herceptin® (trastuzumab), an important monoclonal antibody used in breast cancer therapeutics, is demonstrated using transverse magnetic (TM) mode suspended microring resonators (MRRs). The suspended MRRs are surface functionalized with a single chain fragment variable (scFv) recombinant antibody molecule (designated 2B4) that enables selective capture of denatured Herceptin...
Condition: Breast Cancer Intervention: Drug: Capecitabine Sponsor: Zhejiang Cancer Hospital Not yet recruiting
Condition: Breast Cancer Intervention: Other: Data collection about eligible patients presented to our department from 2015 to 2018. Then follow up for 2 years till 2020. Sponsor: Assiut University Not yet recruiting
Condition: Metastatic Breast Cancer Intervention: Drug: Eribulin Sponsors: Institut Paoli-Calmettes; Eisai Inc. Not yet recruiting
Conditions: Menopausal Patients; Low-risk Breast Cancer Interventions: Radiation: RIOP-Intrabeam® system; Radiation: conventional surgery +RTE Sponsor: Institut Cancerologie de l'Ouest Active, not recruiting
Conclusion: ADC value calculation does not seem to be used as an alternative for histopathological detection, which is the gold standard for the differentiation of subtypes of malignant breast cancer. In addition, since there is a positive correlation between CR/S ratio and ADC values, it may be a strong marker to evaluate the stromal component of lesions. PMID: 30119158 [PubMed - as supplied by publisher]
Authors: Azarnezhad, Tabrizi, Javan, Mehdipour P Abstract Background/aim: The aims of this study were to detect CCND1 , C-MYC , and FGFR1 amplification using qPCR, confirmation with FISH, and to further assess their clinicopathological relevance. Materials and methods: Thirty-five breast tumor samples were analyzed for amplification of the selected genes using modified SYBR Green qPCR. The accuracy of the qPCR was assessed by FISH as a gold-standard method. Results: CCND1 , C-MYC , and FGFR1 amplifications were observed in 34.28%, 28.57%, and 17.14% of the 35 samples, respectively. qPCR results wer...
In conclusion, we suggested that valproate enhanced 3-BrPA-induced cell death. This might be attributable to the increase in cellular ATP consumption owing to valproate-induced MRP2 or BCRP expression.Graphical abstract
MONDAY, Aug. 20, 2018 -- Treatment with lumpectomy and radiotherapy is associated with a reduction in breast cancer mortality versus lumpectomy or mastectomy alone among patients with ductal carcinoma in situ (DCIS), according to a study published...
ACS NanoDOI: 10.1021/acsnano.8b03029