UPMC researchers solving treatment resistance in most common breast cancer

(University of Pittsburgh Schools of the Health Sciences) For the first time researchers have identified recurrent ESR1 fusion proteins in human breast cancer, to understand how they function and help lead to improved treatments for the disease.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Authors: Leung HWC, Leung JH, Chan ALF PMID: 30451021 [PubMed - as supplied by publisher]
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Conditions:   Left-Sided Breast Cancer;   Radiation Toxicity Intervention:   Radiation: Confirmed Left-Sided Breast Cancer Sponsor:   Lawson Health Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Breast Cancer Female Intervention:   Drug: Letrozole Sponsors:   University of Texas Southwestern Medical Center;   Cancer Prevention Research Institute of Texas Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Researchers at the Elizabeth Wende Breast Center in New York say women over the age of 75 should continue to receive routine breast cancer screening because their risk keeps rising with age.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusion: The results of this study suggest that SNPs in thePALB2 loci rs120963/rs249935/rs447529, but not in the other 3 loci (rs152451/rs8053188/rs16940342), may contribute to breast cancer susceptibility.Oncol Res Treat
Source: Oncology Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionPhase II studies regarding PKC- β inhibitor, enzastaurin, showed promising results in MCL, DLBCL and recurrent high-grade gliomas. However, the detailed mechanism is still in need. The mechanism of PKC-β in mediating autophagy in lymphoma and high-grade gliomas remains elusive as well. Moreover, several studies were in agreement that rottlerin enhanced autophagy in breast cancer cells, which warrants further clinical studies to verify PKC-δ as a therapeutic target. Thus, identifying the function of PKC in modulating autophagy and conducting related clinical studies help find novel target for chemotherapy.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionGPC3 is operating through an intricate molecular signaling network. From the balance of these interactions, the inhibition of breast metastatic spread induced by GPC3 emerges.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Women ages 75 and older should continue to undergo screening mammography if...Read more on AuntMinnie.comRelated Reading: Age, not density, predicts interval breast cancer result How serious is the risk of breast cancer overdiagnosis? Breast screening rates fall for older women in ACOs Are older women getting appropriate mammo screening? Do older women benefit from screening mammography?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Jesse M. Mast, Periannan Kuppusamy
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Erik W. J. Mollen, Jonathan Ient, Vivianne C. G. Tjan-Heijnen, Liesbeth J. Boersma, Lucio Miele, Marjolein L. Smidt, Marc A. G. G. Vooijs
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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