Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study.

CONCLUSIONS: Our data support the notion of T-cell occurrence in AD brains and suggest that, in advanced stages of AD, T-cell extravasation is driven by tau-related neurodegenerative changes rather than by cerebral amyloidosis. T cells could be crucial for driving the amyloid-independent phase of the AD pathology.
PMID: 29402847 [PubMed - as supplied by publisher]

Source: Neuro-Degenerative Diseases - February 7, 2018 Category: Neurology Authors: Merlini M, Kirabali T, Kulic L, Nitsch RM, Ferretti MT Tags: Neurodegener Dis Source Type: research