M Ö NCH detector enables fast and low-dose free-propagation phase-contrast computed tomography of in situ mouse lungs
Due to the complexity of the underlying pathomechanism, in vivo mouse lung-disease models continue to be of great importance in preclinical respiratory research. Longitudinal studies following the cause of a disease or evaluating treatment efficacy are of particular interest but challenging due to the small size of the mouse lung and the fast breathing rate. Synchrotron-based in-line phase-contrast computed tomography imaging has been successfully applied in lung research in various applications, but mostly at dose levels that forbid longitudinal in vivo studies. Here, the novel charge-integrating hybrid detector M Ö NCH is presented, which enables imaging of mouse lungs at a pixel size of 25 µ m, in less than 10 s and with an entrance dose of about 70 mGy, which therefore will allow longitudinal lung disease studies to be performed in mouse models.
Source: Journal of Synchrotron Radiation - Category: Physics Authors: Dullin, C. Albers, J. Tromba, G. Andr ä , M. Ramilli, M. Bergamaschi, A. Tags: mouse-lung imaging low dose phase-contrast computed tomography charge-integration detector short communications Source Type: research