Spread of breast cancer linked to compound in asparagus and other foods

Using drugs or diet to reduce levels of asparagine may benefit patients, say researchersBreast cancer patients could be encouraged to cut asparagus and other foods from their diets in the future to reduce the risk of the disease spreading, scientists say.Researchers are investigating whether a change in diet could help patients with breast tumours after studies in mice showed that asparagine, a compound first identified in asparagus but present in many other foods, drives the spread of the disease to other organs.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Cancer research Science UK news Health Medical research Society Source Type: news

Related Links:

Publication date: Available online 18 January 2019Source: Biosensors and BioelectronicsAuthor(s): Ya Cao, Yuhao Dai, Hong Chen, Yingying Tang, Xu Chen, Ying Wang, Jing Zhao, Xiaoli ZhuAbstractIn this work, DNA-templated silver nanoclusters (DNA-AgNCs) with unique fluorescent and electrochemical properties are prepared as dual signal probes for both qualitative imaging and quantitative detection of cancer cells in an integrated system. ITO electrode that has good light transmittance and electric conductivity is employed as a substrate for dual analysis of cancer cells. ITO electrode is firstly modified by AS1141 aptamer, wh...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Quality of life, patient satisfaction and cosmetic outcome after delayed breast reconstruction using DIEP flap: a 10 years' follow-up survey. J Plast Surg Hand Surg. 2019 Jan 18;:1-6 Authors: Skraastad BK, Knudsen C, Jackson C, Utheim TP, Pripp AH, Tønseth KA Abstract Autologous breast reconstruction (BR) aims to restore body image and improve health-related quality of life in women undergoing mastectomy due to breast cancer. We wanted to explore patient-reported cosmetic results and satisfaction 10 or more years post BR surgery, using deep inferior epigastric perforator flap (DIEP). This i...
Source: Journal of Plastic Surgery and Hand Surgery - Category: Surgery Tags: J Plast Surg Hand Surg Source Type: research
Authors: Bobrowska-Korczak B, Skrajnowska D, Seidel K, Bielecki W, Gadzinski B Abstract The aim of the present study was to assess the effect of zinc and copper, separately or in combination with resveratrol, on the concentration of 15-hydroxyeicosatetraenoic acid (15-HETE) in urine of rats with mammary cancer (adenocarcinoma) induced with 7,12- dimethyl-1,2-benz[a]anthracene (+ DMBA). The research focused on the kinetics of alterations in urinary 15-HETE at the early stage of carcinogenesis, as well as on the influence of dietary factors on the process. The content of 15-hydroxyeicosatetraenoic acid in the rats' u...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
CONCLUSIONS: Clinical response to upfront chemotherapy predicts the outcome of patients affected by IBC. PMID: 30656969 [PubMed - as supplied by publisher]
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
The physical and psychological side effects of breast cancer therapies can have substantial impact on survivors' physical and social functioning. Roughly half of the more than 3 million Americans alive with a history of breast cancer report adverse, function-degrading sequelae related to their oncologic treatments. Care delivery models for the timely delivery of rehabilitation services have been proposed yet limitedly vetted or implemented. These include the prospective surveillance model, procedure-linked referrals, survivorship care plans, and risk stratification. Patients' capacity to engage in the rehabilitative proces...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Literature Review Source Type: research
This study sought to test a methodology for estimating over-screening due to excessive periodicity, defined as a smaller than recommended interval between exams, and its association with socio-demographic characteristics. A cohort of women who underwent mammography in 2010, and whose result was normal, was assembled through probabilistic linkage SISMAMA records based on a set of personal identifiers. We used data from women living in the micro health region of Juiz de Fora/Lima Duarte/Bom Jardim, Minas Gerais State, Brazil, who were followed in the System until the end of 2012. The rate of over-screening was 150/1,000 wome...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
Contributors : Sunil Badve ; Yesim Gokmen-PolarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensESRP1 was knocked down in endocrine resistant LCC2 and LCC9 cells
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
CONCLUSIONS TCL-based immunotherapy has discrepant anti-tumor efficiency in different TNBC cell lines by PDL-1/PD interaction, providing the theoretical basis of TCL-based immunotherapy in TNBC. PMID: 30653481 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CDK4/6 inhibitors, namely palbociclib, ribociclib and abemaciclib, belong to a new class of anticancer drugs used for the treatment of patients with hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer. Studies on the structure-activity relationship suggest that the presence of the 2-amino-pyridine group and the piperazine ring (Figure 1) are important molecular determinants for ATP-competitive inhibition and CDK4/6 selectivity [1]. Abemaciclib has the highest CDK4/CDK6 selectivity ratio within the class and the unique ability to target CDK9 at clinically relevant concentrations [2].
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Complications of Treatment Source Type: research
AbstractBackgroundBariatric surgery is associated with a reduced risk of developing certain malignancies, particularly in women. However, the impact of bariatric surgery on tumor characteristics, cancer treatment, and oncologic outcomes is unknown.MethodIn a retrospective cohort study, 42 subjects diagnosed with breast cancer after bariatric surgery (1989 –2014) were matched to 84 subjects with breast cancer (1984–2012) who did not undergo bariatric surgery, based on age, body mass index (BMI), and menopausal status at the time of breast cancer diagnosis, as well as the date of cancer diagnosis. Medical records...
Source: Obesity Surgery - Category: Surgery Source Type: research
More News: Asparagus | Breast Cancer | Cancer | Cancer & Oncology | Diets | Nutrition | Research | Science | Study