Medical News Today: Brain-repairing protein may lead to new MS drugs

The mechanism set in motion by a protein implicated in the repair of myelin damage could hold the key to a better treatment for multiple sclerosis.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news

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Drugs that help repair the nerve cell lining that ’s damaged in multiple sclerosis were found to target certain enzymes. The finding could help researchers develop new treatments for multiple sclerosis.
Source: NIH Research Matters from the National Institutes of Health (NIH) - Category: Consumer Health News Source Type: news
In this study we assessed the effect of fingolimod on transplanted human induced pluripotent stem cell derived neural progenitors (hiPSC-NPs). hiPSC-NPs were labeled by green fluorescence protein (GFP) and transplanted into the corpus callosum of mice which were chronically demyelinated after cuprizone (CPZ) feedings for 10 weeks. The animals received fingolimod from 1 day prior to NPs transplantation via gavage as well as daily intraperitoneal cyclosporine A from 2 days before cell transplantation until the time of sampling. At either 7 or 21 days after NPs transplantation, the animals were sacrificed and their brains wer...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
In conclusion, these results indicated that hAMC could attenuate the inflammation and promote the remyelination in EAE mice, which might be a promising cell source for the therapy of MS. PMID: 30035132 [PubMed - in process]
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Scientists determined how drugs can repair damaged brain cells that cause multiple sclerosis, and possibly other degenerative neurological diseases.
Source: Health News - - Category: Consumer Health News Source Type: news
Authors: Genc B, Bozan HR, Genc S, Genc K Abstract Multiple sclerosis (MS) is a chronic inflammatory, autoimmune, and neurodegenerative disease of the central nervous system (CNS). It is characterized by demyelination and neuronal loss that is induced by attack of autoreactive T cells to the myelin sheath and endogenous remyelination failure, eventually leading to functional neurological disability. Although recent evidence suggests that MS relapses are induced by environmental and exogenous triggers such as viral infections in a genetic background, its very complex pathogenesis is not completely understood. Theref...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
(Case Western Reserve University) Research published today in the journal Nature provides new understanding about how drugs can repair damaged brain cells that cause disability in patients with multiple sclerosis. Led by researchers at Case Western Reserve University School of Medicine, the study suggests new drug targets and potent early-stage drug candidates could lead to regenerative medicines for multiple sclerosis and other debilitating neurological diseases.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 20 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Gareth Pryce, David BakerAbstractSince their discovery, the existence of secreted oligoclonal immunoglobulin in the central nervous system in people with multiple sclerosis has been the subject of scientific investigation and debate over several decades. Although autoantibodies can be detected in some individuals, probably secondary to release of neo-antigens after damage, evidence for a major, primary involvement of damaging antibodies is still relatively lacking. However it is possible to construct a working hypothes...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
(University of the Basque Country) In the lab it was possible to improve the symptoms in the chronic phase of the disease while encouraging the repair of the nervous tissue, and the challenge now is to move the research forward in humans. This discovery is the outcome of the work by an international consortium led in the Basque Autonomous Community by the UPV/EHU and the Achucarro centre together with personnel from ciberNed and CICbiomaGUNE.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Saeideh Baradaran, Akbar Hajizadeh Moghaddam, Maryam Ghasemi-KasmanAbstractVisual impairment is considered as the most common initial manifestation of multiple sclerosis (MS) patients. It has been shown that hesperetin (Hst), a flavonoid of citrus fruit, possesses anti-inflammatory and antioxidant effects both in vitro and in vivo. The present study was designed to evaluate the pharmacological/medicinal effects of Hst treatment on myelin repair and glial activation in lysolecithin (LPC)-induced focal demyelination model. In order to induce local de...
Source: Life Sciences - Category: Biology Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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