Learning a language could protect you from Alzheimer's
MRI scans of patients with Alzheimer's showed they retained more of their gray matter in crucial brain areas if they were bilingual, according to researchers at Concordia University in Canada.
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impa...
Discussion Although Aβ did not differ by sex, cognitive decline was greater in females with higher Aβ. Our findings suggest that sex may play a modifying role on risk of Alzheimer's disease–related cognitive decline.
In a recent paper, researchers provided evidence to suggest that the risk factors associated with cardiovascular decline with age interact with amyloid-β in the brain to accelerate cognitive decline. Having more of both produces a worse prognosis, which is not all that surprising. This is the case in many areas of aging and age-related disease: forms of damage and dysfunction interact with one another, making consequences worse than would be the case if they were independent of one another. This is one of the reasons why aging is an accelerating process, starting off slow and picking up pace ever more rapidly as the d...
CONCLUSIONS: Further studies using biomarker-underpinned diagnoses are warranted to shed more light on the potential diagnostic utility of BACE1 activity as AD biomarker candidate in MCI. PMID: 29788013 [PubMed - as supplied by publisher]
PET scans of normal older adults can detect which ones are likely to decline...Read more on AuntMinnie.comRelated Reading: PET with novel tracers foretells early Alzheimer's risk PiB-PET study strengthens link between amyloid, dementia Flortaucipir-PET could lead in early Alzheimer's detection High amyloid levels on PET may indicate early Alzheimer's PET links midlife vascular risk factors to more amyloid
In conclusion, PCC hypometabolism is not restricted to AD.
AbstractHippocampal atrophy measures from magnetic resonance imaging (MRI) are powerful tools for monitoring Alzheimer ’s disease (AD) progression. In this paper, we introduce a longitudinal image analysis framework based on robust registration and simultaneous hippocampal segmentation and longitudinal marker classification of brain MRI of an arbitrary number of time points. The framework comprises two innovative parts: a longitudinal segmentation and a longitudinal classification step. The results show that both steps of the longitudinal pipeline improved the reliability and the accuracy of the discrimination betwee...
Discussion These results support the feasibility of bridging of clinical trials in the prodromal stage of AD between Asia and western countries.
This study supports the investigation of the role of myelination in MCI and dementia through use of this quantitative magnetic resonance imaging approach in clinical studies of disease progression, relationship of functional status to myelination status, and therapeutics. Furthermore, mapping MWF may permit myelin to serve as a therapeutic target in clinical trials.
Contradictory findings on the role of the type 1 cannabinoid receptor (CB1R) during the pathogenesis of Alzheimer ’s disease (AD) have been reported. Here, we evaluated the CB1R brain profile in an AD mouse model using longitudinal positron emission tomography (PET) with an inverse agonist for CB1R, [18F]FMPEP-d2. APP/PS1-21 and wild-type (n = 8 in each group) mice were repeatedly imaged between 6 to 15 month s of age, accompanied by brain autoradiography, western blot, and CB1R immunohistochemistry with additional mice.