HDR Brachytherapy as Monotherapy for Low and Intermediate Risk Prostate Cancer

Condition:   Prostate Cancer Intervention:   Radiation: HDR brachytherapy as monotherapy Sponsor:   CR-CSSS Champlain-Charles-Le Moyne Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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This study aimed to assess the reduction in dose to the penile bulb (PB) achieved by MRI-based contouring following drinking and endorectal balloon (ERB) instructions.Patients and methodsA total of 17  prostate cancer patients were treated with intensity-modulated radiation therapy (IMRT) and interstitial brachytherapy (IBT). CT and MRI datasets were acquired back-to-back based on a 65 cm3 air-filled ERB and drinking instructions. After rigid co-registration of the imaging data, the CT-based planning target volume (PTV) used for treatment planning was retrospectively compared to an MRI-based adaptive PTV and th...
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
Surgery and radiotherapy are considered as standard treatments in every risk groups of localized prostate cancer. Regarding radiotherapy, it is well established that dose escalation improves biochemical-progression-free survival (b-PFS) and less likely overall survival (OS) [1 –3].
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Systematic or Meta-analysis Studies Source Type: research
We report the primary endpoint of the phase 2 NRG/RTOG 0526 trial of salvage low dose rate prostate brachytherapy for locally recurrent prostate cancer following prior external beam radiotherapy (EBRT). Eligible patients initially presented with favorable or intermediate risk prostate cancer. At a median follow up of 54 months, 12 of 92 analyzable patients (14%) had late grade 3 gastrointestinal or genitourinary adverse events, which did not exceed the previously set threshold for unacceptable toxicity.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
Purpose of review With the increasing incidence of low-to-intermediate risk of prostate cancer (PCa) by the introduction of prostate-specific antigen (PSA) screening, focal therapy has become one of the promising treatment options in the world. In Asia, same movement are occurring using several technologies including cryoablation, high-intensity focused ultrasound, brachytherapy and irreversible electroporation. However, these are still not common strategies to treat organ-confined PCa. The purpose of this review is to summarize the most updated experience and future direction of focal therapy in Asian countries. Recent...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: FOCAL THERAPY OF PROSTATE AND KIDNEY CANCER: Edited by Jean de la Rosette and Thomas J. Polascik Source Type: research
CONCLUSION: Metformin use in this analysis appears to be associated with better BCR and OS. Larger datasets and prospective trials are warranted to validate these results. PMID: 30281009 [PubMed - in process]
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
To report outcomes of patients undergoing low-dose-rate (LDR) brachytherapy and investigate factors associated with biochemical failure and survival.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSIONS: Our results suggest that focal salvage HDR brachytherapy is well tolerated and promising. External validation is needed. PMID: 30244878 [PubMed - in process]
Source: Health Physics - Category: Physics Authors: Tags: Int J Radiat Oncol Biol Phys Source Type: research
Authors: Zimmermann JS, Osieka R, Bruns T, Hollberg H, Wiechmann B, Netzbandt O, Sablotny J, Malade M, Heitz M, Bernhardt F, Tiemann J, Wilkens M, Brüske T, Welker U, Heinemann V, Zimmermann P, de la Maza SF, Pfeiffer D, Tauber PR, Thomas D, Moustakis C Abstract Purpose: To assess the effectiveness of low-dose-rate (LDR) brachytherapy in patients with localized prostate cancer and to compare the outcome with predictions from Kattan and Partin nomograms at 60 months after seed implantation. Material and methods: One thousand, one hundred and eighty-seven patients with localized prostate cancer at low-, inte...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
This study aimed to evaluate and compare plan reproducibility of intraoperatively built custom linked seeds and loose seeds for prostate brachytherapy. Material and methods: Between December 2010 and March 2014, 76 localized prostate cancer patients received Iodine-125 brachytherapy with external beam radiotherapy. Linked and loose seeds were implanted in 39 and 37 patients, respectively. The primary endpoint was the mean (± standard deviation) of the absolute change in the minimum dose received by 90% of the prostate volume between intraoperative and post-operative planning (ΔD90) to confirm plan reproduc...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Authors: Grisotto S, Cerrotta A, Pappalardi B, Carrara M, Messina A, Tenconi C, Valdagni R, Fallai C Abstract Purpose: The purpose of this study was to compare the prostate contours drawn by two radiation oncologists and one radiologist on magnetic resonance (MR) and transrectal ultrasound (TRUS) images. TRUS intra- and inter-fraction variability as well as TRUS vs. MR inter-modality and inter-operator variability were studied. Material and methods: Thirty patients affected by localized prostate cancer and treated with interstitial high-dose-rate (HDR) prostate brachytherapy at the National Cancer Institute in ...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
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