Serum Uric Acid Levels and Onset of Cardiovascular Diseases: a CALIBER Study

Conditions:   Stable Angina;   Unstable Angina;   Myocardial Infarction;   Unheralded Coronary Heart Disease Death;   Heart Failure;   Cardiac Arrest;   Transient Ischaemic Attack;   Ischemic Stroke;   Subarachnoid Hemorrhage;   Intracerebral Hemorrhage;   Peripheral Arterial Disease ;   Abdominal Aortic Aneurysm;   Atrial Fibrillation Intervention:   Sponsors:   University College, London;   Wellcome Trust;   National Institute for Health Research, United Kingdom;   Medical Research Council Active, not recruiting
Source: - Category: Research Source Type: clinical trials

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We describe the current state of the art of percutaneous LAAO in atrial fibrillation patients with a high hemorrhagic risk.
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Reviews Source Type: research
This report suggests a possible association between pituitary apoplexy and vardenafil use. In patients with preexisting pituitary adenoma, vardenafil may enhance the risk of pituitary apoplexy. Although headache is the most commonly reported side effect of vardenafil, pituitary apoplexy should be considered in the differential diagnosis of a patient with headache and ophthalmoplegia subsequent to vardenafil intake.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
Conditions:   Cerebrovascular Stroke;   Intracranial Hemorrhages;   Anticoagulant;   Matrix Metalloproteinases Intervention:   Drug: Rivaroxaban Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Bayer Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Authors: Kreuziger LB, Massicotte MP Abstract Mechanical circulatory support (MCS) is the overarching term that encompasses the temporary and durable devices used in patients with severe heart failure. MCS disturbs the hematologic and coagulation system, leading to platelet activation, activation of the contact pathway of coagulation, and acquired von Willebrand syndrome. Ischemic stroke and major hemorrhage occur in up to 30% of patients. Hematologists are an essential part of the MCS team because they understand the delicate balance between bleeding and clotting and alteration of hemostasis with antithrombotic th...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
Authors: Karamouzis I, Caputo M, Mele C, Nuzzo A, Zavattaro M, Car P, Panzarasa G, Prodam F, Marzullo P, Aimaretti G Abstract OBJECTIVE: To evaluate early results of transsphenoidal surgery for pituitary adenomas. DESIGN: Retrospective evaluation of 90 consecutive patients undergoing endoscopic pituitary adenoma surgery (2007-2016) at "Maggiore della Carità" Hospital in Novara, Italy. Age at diagnosis, sex, symptoms at presentation, hormonal and radiological data, complications of surgery, and short-term follow-up information were collected. RESULTS: The majority of patients were male (M/F:...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
5'-AMP-activated protein kinase (AMPK), a member of the serine/threonine (Ser/Thr) kinase group, is universally distributed in various cells and organs. It is a significant endogenous defensive molecule that responds to harmful stimuli, such as cerebral ischemia, cerebral hemorrhage, and, neurodegenerative diseases (NDD). Cerebral ischemia, which results from insufficient blood flow or the blockage of blood vessels, is a major cause of ischemic stroke. Ischemic stroke has received increased attention due to its '3H' effects, namely high mortality, high morbidity, and high disability. Numerous studies have revealed that act...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
This study found a higher HHT prevalence in Alberta (1 in 3800) compared to the world average of 1 in 5000. Women were also more likely to be diagnosed with HHT, with a 3.25:1 female gender preponderance in the yearly incidence.InterpretationThis study not only shows that HHT patients are at higher risk of having a stroke but also quantifies that risk using an age-adjusted metric in Alberta. This province has a higher than expected disease burden of HHT, with the majority of cases affecting women. Our study found that acute ischemic strokes and transient ischemic attacks are far more common than hemorrhage in HHT. As HHT i...
Source: The Canadian Journal of Neurological Sciences - Category: Neurology Authors: Tags: Can J Neurol Sci Source Type: research
Semin Neurol 2018; 38: 627-633 DOI: 10.1055/s-0038-1673681Headache is a neurologic disorder that displays gender dichotomy. It is well established that there is a strong link between migraine headache and sex hormones, specifically estrogen, which influences the severity of migraines during the menstrual cycle, pregnancy, and menopause. Furthermore, the epidemiology of headaches during pregnancy and the postpartum period is very distinct from that in males or nonpregnant females, in part due to the hemodynamic and hematologic changes that occur during pregnancy. These changes put women at higher risk for cerebral venous th...
Source: Seminars in Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research
ConclusionA higher proportion of nurses-staffing level is associated with better performance of acute care services in OECD countries. Also, the nursing characteristics of Sweden, Denmark, Canada, Netherlands, Finland, Switzerland, Australia and United States would be good patterns for other countries to maximize nursing outcomes in the care of patients with acute and life-threatening conditions by reducing the risk of complication, mortality and adverse clinical outcomes.
Source: International Journal of Nursing Sciences - Category: Nursing Source Type: research
ConclusionsThe incidence of epilepsy was high and increased with age in elderly patients followed in general practices in Germany. Addressing identified risk factors may help reduce the risk of developing epilepsy.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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