From the heart: The tale of a three-time transplant recipient
Playing youth hockey and Little League in the spring of 1988, I started to become easily fatigued. I became very weak and could no longer run around. By May, a visit to my pediatrician resulted in a trip to the Boston Children’s Hospital Cardiology Clinic on Fegan 6 and the first of many cardiac catheterizations I would receive in my life. The results of that first procedure were shared in my corner room across from the nurses’ station on 6 East (the cardiac step-down at the time): I would need a heart transplant for cardiomyopathy. It was Friday the 13th. I was 10 years old. Tim, before he was diagnosed with cardiomyopathy The first of two heart transplants In July 1988, I had the seventh heart transplant ever performed at Boston Children’s. Dr. Mayer was my surgeon. Incredibly, a friend, who was waiting for a heart at the same time, had received the sixth heart transplant the night before. Up until this point, aside from asthma, I was a healthy, athletic kid. As I adjusted to my new reality, I noticed that many other heart patients at Boston Children’s had been born with congenital heart problems and had been going to the hospital their entire lives. It was a humbling observation and made an impression on me — these other kids had been sick for a lot longer and likely had it a lot tougher, so I made the decision not to take a “woe is me” attitude. That is not to say I haven’t had difficult or stressful time...
In the article entitled, “Myofilament Remodeling and Function Is More Impaired in Peripartum Cardiomyopathy Compared with Dilated Cardiomyopathy and Ischemic Heart Disease” (Volume 187, pages 2645–2658 of the December 2017 issue of The American Journal of Pathology; https://doi.org/10.1016/j.ajpath.2017.08.022), there are two issues in figures that need to be updated.
No abstract available
Abstract Cord blood transplantation (CBT) is an effective option for treating hematological malignancies, but graft failure (GF) remains the primary cause of therapy failure. Thus, based on myeloablative conditioning (MAC) of busulfan with cyclophosphamide (Bu/Cy) or total body irradiation with Cy (TBI/Cy), fludarabine (Flu) was added to Bu/Cy and cytarabine (CA) to TBI/Cy for a modified myeloablative conditioning (MMAC). To compare the prognosis of MMAC with MAC, we conducted a retrospective study including 58 patients who underwent CBT with MAC or MMAC from 2000 to 2011. Neutrophil and platelet engraftment rate, overall ...
Camille Ribeyre, Federico Carlini, C éline René, François Jordier, Christophe Picard, Jacques Chiaroni, Laurent Abi-Rached, Philippe Gouret, Grégory Marin, Nicolas Molinari, Pascal Chanez, Julien Paganini, Delphine Gras, Julie Di Cristofaro
Authors: Osada N, Kikuchi J, Umehara T, Sato S, Urabe M, Abe T, Hayashi N, Sugitani M, Hanazono Y, Furukawa Y Abstract Human induced pluripotent stem cells (hiPSCs) are creating great expectations for regenerative medicine. However, safety strategies must be put in place to guard against teratoma formation after transplantation of hiPSC-derived cells into patients. Recent studies indicate that epigenetic regulators act at the initial step of tumorigenesis. Using gain-of-function and loss-of-function approaches, we show here that the expression and function of lysine-specific demethylase 1 (LSD1) are tightly regulat...
Four-year-old Michael Pownwall of Philadelphia is donating bone marrow to both of his twin brothers. The transplant will give the boys the immunity they were born without due to a rare genetic disease.
Conclusions: The English HeartQoL health-related quality of life questionnaire is valid, reliable, and responsive in patients with angina and myocardial infarction allowing (1) assessment of baseline, (2) between-diagnosis comparisons, and (3) evaluation of change over time.
Conclusions: Two-thirds of our sample with advanced IPF referred to lung transplant successfully attended PR and improved exercise capacity and HRQL, without association with markers of disease severity. No difference was found at baseline compared with subjects who were not able to complete the program.
Conclusions: After CR, overweight patients showed the best improvement in subjective health status. CR did not significantly improve subjective health status in normal-weight and obese patients.
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