From the heart: The tale of a three-time transplant recipient
Playing youth hockey and Little League in the spring of 1988, I started to become easily fatigued. I became very weak and could no longer run around. By May, a visit to my pediatrician resulted in a trip to the Boston Children’s Hospital Cardiology Clinic on Fegan 6 and the first of many cardiac catheterizations I would receive in my life. The results of that first procedure were shared in my corner room across from the nurses’ station on 6 East (the cardiac step-down at the time): I would need a heart transplant for cardiomyopathy. It was Friday the 13th. I was 10 years old. Tim, before he was diagnosed with cardiomyopathy The first of two heart transplants In July 1988, I had the seventh heart transplant ever performed at Boston Children’s. Dr. Mayer was my surgeon. Incredibly, a friend, who was waiting for a heart at the same time, had received the sixth heart transplant the night before. Up until this point, aside from asthma, I was a healthy, athletic kid. As I adjusted to my new reality, I noticed that many other heart patients at Boston Children’s had been born with congenital heart problems and had been going to the hospital their entire lives. It was a humbling observation and made an impression on me — these other kids had been sick for a lot longer and likely had it a lot tougher, so I made the decision not to take a “woe is me” attitude. That is not to say I haven’t had difficult or stressful time...
Conclusion: Topical minoxidil is efficacious for the treatment of hair loss due to male and female androgenic alopecia, alopecia areata, with case-by-case application for traction alopecia, hair transplantation, and congenital hair disorders. Combination therapies using minoxidil with systemic, topical, and injectable therapies demonstrate increased effectiveness over monotherapies. J Drugs Dermatol. 2019;18(2):155-160. PMID: 30794366 [PubMed - as supplied by publisher]
In conclusion, it is a novel antimicrobial peptide discovered from the skin secretion of Limnonectes fujianensis, and particularly effective against both planktonic and sessile MRSA. The further in vivo study suggests that Japonicin-2LF could be a potential drug candidate to control the MRSA infection in cystic fibrosis patients.
Authors: Jiang C, Jiang L, Qin Q Abstract Objectives: The efficacy of conventional treatments plus acupuncture for asthma in adult and adolescent is uncertain. Literature reports are conflicting; therefore, the aim of this study was to determine the efficacy of conventional treatments plus acupuncture versus conventional treatments alone using a meta-analysis of all published randomized clinical trials (RCTs). Methods: Two reviewers independently performed a comprehensive literature search from multiple electronic sources (1990-2018), including PubMed, EMBASE, the Cochrane Library, Web of Science, China Nationa...
Publication date: Available online 22 February 2019Source: The Lancet Respiratory MedicineAuthor(s): Warren Lenney, Yuichi Adachi, Andrew Bush, Gilberto B Fischer, Jianguo Hong, Anders Ostrem, Soren Pedersen, Peter D Sly, Stanley J Szefler, Raj Tilak, Heather J Zar, Yuichi Adachi, Lara J Akinbami, Kathryn V Blake, Andrew Bush, Michael Cabana, Lisa C Cicutto, Adnan Custovic, Iolo Doull, Gilberto B Fischer
We present our experience with hypothermic machine perfusion (HMP) versus cold storage (CS) in relation to kidney transplant outcomes. Methods: Retrospective analysis of 33 consecutive HMP kidney transplant outcomes matched with those of 33 cold stored: delayed graft function (DGF), length of hospital stay (LOS), estimated glomerular filtration rate (eGFR), and patient and graft survival were compared. Renal Resistive Indexes (RIs) during HMP in relation to DGF were also analysed. Results: In the HMP group, mean HMP time was 5.7 ± 3.9 hours with a mean cold ischaemic time (CIT) of 15 ± 5.6 versus 15...
ConclusionThis study highlights the ongoing risk of opportunistic infection several years after transplantation and adds weight to potential person to person Pneumocystis jirovecii transmission. Risk factors have been identified which may highlight those most at risk, allowing targeted rather than blanket long-term PCP prophylaxis.
Publication date: April 2019Source: Biomedicine &Pharmacotherapy, Volume 112Author(s): Jie Cui, Fei Xu, Zhao Tang, Wenqian Wang, Ling li Hu, Chen Yan, Qingli Luo, Hongjian Gao, Ying Wei, Jingcheng DongAbstractBu-Shen-Yi-Qi formula (BSYQF) could suppress chronic airway inflammation according to previous studies. However, there is relatively little direct experimental evidence to evaluate the effects of BSYQF treatment on airway remodeling in chronic asthma. Recent evidence suggests that oxidative stress is involved in airway inflammation and airway remodeling in chronic asthma. BSYQF which includes various of chemical c...
Publication date: March 2019Source: Revista Española de Cardiología (English Edition), Volume 72, Issue 3Author(s): Nicolás M. Maneiro-Melón, Miguel González-Barbeito, Francisco Estévez-Cid, Jesús Peteiro-Vázquez, José J. Cuenca-Castillo, Roberto Barriales-Villa
Publication date: March 2019Source: Revista Española de Cardiología (English Edition), Volume 72, Issue 3Author(s): José Luis Martínez-Sande, Javier García-Seara, Laila González-Melchor, Moisés Rodríguez-Mañero, Inés Gómez-Otero, José Ramón González-Juanatey
Publication date: Available online 23 February 2019Source: American Heart JournalAuthor(s): Leigh White, Ruan Vlok, Thomas Melhuish
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