Prostate Cancer: A Contemporary Approach to Treatment and Outcomes.
Prostate Cancer: A Contemporary Approach to Treatment and Outcomes. Med Clin North Am. 2018 Mar;102(2):215-229 Authors: Weiner AB, Kundu SD Abstract Given the high incidence of prostate cancer and the need for shared decision-making before screening, it is imperative that primary care providers understand treatment options and treatment adverse effects. In this review article, the treatment options for the localized and metastatic prostate cancer are discussed, including the different modalities and their indications, adverse effects, oncologic outcomes, posttreatment monitoring, and potential treatment options following cancer recurrence. PMID: 29406054 [PubMed - in process]
(Reuters Health) - Men with prostate cancer who get the gland removed may be just as likely to suffer after-effects like erectile dysfunction and urinary incontinence with robotic surgery as with other operations, a UK study suggests.
The observed narrowing of racial disparities in prostate cancer outcome since the advent of PSA screening is not as large as previously believed.
ConclusionPatients who have undergone prostate biopsy and treatment decision-making for Pca experience a decline in HRQoL. Choosing treatment with a curative intent was associated with greater decline in HRQoL. Interventions aimed at optimism and decision self-efficacy could be helpful to reduce HRQoL impairment around the time of prostate biopsy and treatment decision-making.
CARY, N.C. (February 21, 2018) —Biologics, Inc., a McKesson Specialty Health oncology and complex care pharmacy services company, has been selected by the Janssen Pharmaceutical Companies of Johnson&Johnson1 to be in the limited distribution network for ERLEADA™ (apalutamide), the first FDA-approv...
Series Type : Expression profiling by array ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
Contributors : Marcin Cieslik ; Yajia ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe goal of this analysis is to profile AR-regulated genes, especially non-coding RNAs in three androgen sensitive prostate cancer cell lines, MDA-PCA-2B, LNCaP and VCaP. The two cell lines were serum-starved first, followed by dihydrotestosterone (DHT) stimulation or treated with Enzalutamide (AR inhibitor) without starvation. Transcriptome profiling was generated by RNA-sequencing from polyA-selected RNA. These experiments are followed by knock-down experiments of AR and ARlnc1 in MDA-PCA-2B, ...
Contributors : Filippo Cortesi ; Gloria Delfanti ; Arianna Calcinotto ; Francesca Gorini ; Ferdinando Pucci ; Michele De Palma ; Andrea Grilli ; Alessandra Recchia ; Silvio Bicciato ; Matteo Bellone ; Giulia Casorati ; Paolo DellabonaSeries Type : Expression profiling by arrayOrganism : Mus musculusTo investigate the impact of the iNKT cells on the tumor-infiltrating leukocytes in TRAMP mouse prostate cancer.
Prostate cancer patients are commonly treated with external beam radiation therapy (RT) and, thanks to modern treatment techniques such as intensity modulated RT and image guided RT that limit dose outside of the prostate, the acute traditional 7- to 9-week course of external beam treatment is generally uneventful with modest morbidity. However, occasionally, there are patients in whom substantial acute symptoms develop, often urinary, who might require a treatment interruption, thus increasing their overall treatment time (OTT).
It is now more than 18 years since Brenner and Hall (1) and, in the same year, Duchesne and Peters (2), independently suggested that there was a strong radiobiological rationale, specific to prostate cancer, for hypofractionating prostate cancer radiation therapy. In short, this was because the slow-growing nature of mo st prostate cancers results in their response to changes in fractionation being similar to those of the surrounding late-responding normal tissues. Consequently, as compared with standard 40-45 fraction treatment protocols for prostate cancer radiation therapy, smaller numbers of higher-dose fractio n...
Conclusions: Enhancing family cohesion and communication within the family can improve the spouses’ HRQOL. Findings regarding sex differences serve as a rationale for gender-based approaches to improving HRQOL in survivorship care in the family context. Implications for Practice: Couple- and/or family-based interventions should be designed to enhance family cohesion and improve family communication skills for effective adjustments within couples and families. Supportive care within the family context can be promoted to address the diverse challenges of survivorship care.