Log in to search using one of your social media accounts:

 

The poly (ADP ribose) polymerase inhibitor niraparib: Management of toxicities.

The poly (ADP ribose) polymerase inhibitor niraparib: Management of toxicities. Gynecol Oncol. 2018 Jan 31;: Authors: Moore KN, Mirza MR, Matulonis UA Abstract Niraparib is an oral poly(ADP ribose) polymerase (PARP) inhibitor that is currently approved by the United States Food and Drug Administration (US FDA) as well as recently approved by the European Medicines Agency (EMA) for the maintenance treatment of women with recurrent ovarian cancer who are in complete or partial response to platinum-based chemotherapy. The mechanisms of action of niraparib include inhibition of PARP enzymatic activity as well as increased formation of PARP-DNA complexes through "trapping" the PARP enzyme on damaged DNA. Phase I and III studies have demonstrated activity and benefit of niraparib in both BRCA mutated (BRCAm) and BRCA wild-type (BRCAwt) cancers. Phase I testing of niraparib established the maximally tolerated dose of 300mg by mouth (PO) daily, and the phase 3 ENGOT-OV16/NOVA study demonstrated the benefit of niraparib maintenance therapy compared to placebo after completion of and response to platinum-based chemotherapy in both BRCAm and BRCAwt ovarian cancer patient populations. Toxicities seen with niraparib include hematologic, gastrointestinal, fatigue, and cardiovascular. Hematologic toxicities include thrombocytopenia, anemia, neutropenia and leukopenia; upfront dose modification to 200mg niraparib for patients with baseline weight of ≤77kg a...
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Tags: Gynecol Oncol Source Type: research

Related Links:

Authors: Kamstra R, Pilon D, Lefebvre P, Emond B, Joshi K Abstract OBJECTIVE: To compare treatment patterns and Medicaid spending between schizophrenia patients initiating once-monthly paliperidone palmitate (PP1M) and oral atypical antipsychotics (OAA) within four comorbid populations: cardiovascular disease (CVD), diabetes, hypertension, and obesity. METHODS: Five-state Medicaid data identified comorbid adults with schizophrenia initiating PP1M or OAA (index) from 09/2009 balanced with inverse probability of treatment weighting. Chi-squared and t-tests compared index antipsychotic (AP) exposure (no gap>90 ...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Authors: Zhao J, Guo N, Zhang L, Wang L Abstract INTRODUCTION: CA125 has poor sensitivity and low specificity for detecting early ovarian cancer. Serum ferritin is elevated in many malignancies. We evaluated the performance of ferritin alone and in combination with CA125 as a diagnostic tool to detect epithelial ovarian cancer (EOC). METHODS: CA125 and ferritin were detected in the serum of 50 healthy control (HC), 50 women with benign gynaecological conditions and 124 women with EOC. The relationship between serum ferritin and CA125 and each of the clinicopathological parameters was assessed, and their diagnos...
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
Hundreds of hardy Penn State students have raised more than $10 million for pediatric cancer patients in the annual 46-hour dance marathon known as Thon
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Authors: Petrou P Abstract INTRODUCTION: The therapeutic categories of Tyrosine Kinase Inhibitors of Vascular Endothelial Growth Factor Receptors, mammalian target of rapamycin inhibitors and Programmed Death-1 inhibitors have transformed the treatment of metastatic renal cell cancer. Nevertheless, this comes at an increased cost, in tandem with similar fiscal pressures in the broader oncology sector, which may jeopardize the sustainability of health systems. Areas covered To this direction, the economic evaluation of these agents is essential for rational and efficient resource allocation. The aim of this study is...
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
Thread Starter Oncogenes explained? Follow 2 minutes ago 2m ago Quote: Originally Posted by MedStudentt Does anyone know any good sites that explain the molecular biology underpining oncogenes especially TP53 and Rb? Specifically in relation to HPV virus and cervica...
Source: The Student Room - Category: Universities & Medical Training Authors: Tags: Medicine Source Type: forums
CONCLUSIONS: Since the onset of the economic crisis in Spain the rate of decline in cancer mortality has slowed significantly, and this situation could be exacerbated by the current austerity measures in healthcare. PMID: 29452751 [PubMed - as supplied by publisher]
Source: Gaceta Sanitaria - Category: International Medicine & Public Health Tags: Gac Sanit Source Type: research
Inflammatory skin diseases cause more harm than skin cancers when years of disability and mortality are added together, according to the latest report from the Global Burden of Disease Study.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Dermatology News Source Type: news
Flatiron ’s key insight was that, in cancer, half or more of the most important data in health records isn’t in structured data fields, but rather in unstructured data, the free text fields of pathology reports and clinical notes, and extracting this information (at least today) requires people.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Authors: Louro H Abstract The manufactured nanomaterials (NMs) have specific physicochemical properties that confer unique mechanical, optical, electrical and magnetic characteristics that are beneficial for biomedical and industrial applications. However, recent studies have suggested that such specific physicochemical properties of the NMs may define nano-bio interactions thereby determining their toxic potential.One of the major concerns about NMs is the potential to induce cancer, suggested by some experimental studies, as seen for titanium dioxide nanomaterials or carbon nanotubes. To analyze in a short term t...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Girigoswami K Abstract In the recent times, nanomaterials are used in many sectors of science, medicine and industry, without revealing its toxic effects. Thus, it is in urgent need for exploring the toxicity along with the application of such useful nanomaterials. Nanomaterials are categorized with a particle size of 1-100 nm. They have gained increasing attention because of their novel properties, including a large specific surface area and high reaction activity. The various fundamental and practical applications of nanomaterials include drug delivery, cell imaging, and cancer therapy. Nanosized semicon...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
More News: Acute Leukemia | Acute Myeloid Leukemia | Anemia | Cancer | Cancer & Oncology | Cardiology | Cardiovascular | Chemotherapy | European Medicines Agency (EMA) | Food and Drug Administration (FDA) | Gastroenterology | Heart | Hematology | Hypertension | Immunotherapy | Leukemia | Myelodysplastic Syndrome | Oral Cancer | Ovarian Cancer | Ovaries | Study | Thrombocytopenia | Toxicology | USA Health | Women