Integrated Approaches to Testing and Assessment: OECD Activities on the Development and Use of Adverse Outcome Pathways and Case Studies

This article reviews recent OECD activities on the use of AOPs in developing Integrated Approaches to Testing and Assessments (IATAs). The guidance document for the use of AOPs in developing IATA, published in 2016, provides a framework for developing and using IATA and describes how IATA can be based on an AOP. The guidance document on the reporting of defined approaches to be used within IATA, also published in 2016, provides a set of principles for reporting defined approaches to testing and assessment to facilitate their evaluation. In the guidance documents, the AOP concept plays an important role for building IATA approaches in a science‐based and transparent way. In 2015, the IATA Case Studies Project was launched to increase experience with the use of IATA and novel hazard methodologies by developing case studies, which constitute examples of predictions that are fit‐for‐regulatory use. This activity highlights the importance of international collaboration for harmonizing and improving chemical safety assessment methods.

Source: Basic and Clinical Pharmacology and Toxicology - February 7, 2018 Category: Drugs & Pharmacology Authors: Yuki Sakuratani, Masashi Horie, Eeva Leinala Tags: MiniReview Source Type: research