Fibrosis in ulcerative colitis is directly linked to severity and chronicity of mucosal inflammation

Summary BackgroundFibrosis in ulcerative colitis has remained largely unexplored despite its clinical implications. AimsThis cross‐sectional study was aimed at characterising the presence, anatomical location and degree of ulcerative colitis‐associated fibrosis and its possible link to clinical parameters. MethodsSeven hundred and six individual tissue cross‐sections derived every 10 cm along the length of 89 consecutive Ulcerative colitis colectomy specimens were examined and compared to Crohn's disease colitis, diverticular disease and uninvolved areas from colorectal cancer patients. Degree of inflammation, fibrosis and morphometric measurements of all layers of the intestinal wall were evaluated. Three gastrointestinal pathologists independently assessed colon sections stained with haematoxylin and eosin, Masson trichrome and Sirius red. Clinical data were collected prospectively. ResultsSubmucosal fibrosis was detected in 100% of ulcerative colitis colectomy specimens, but only in areas affected by inflammation. Submucosal fibrosis was associated with the severity of intestinal inflammation (Spearman correlations rho (95% confidence interval): 0.58 (P
Source: Alimentary Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research

Related Links:

Publication date: Available online 14 October 2019Source: Food ChemistryAuthor(s): Jianghao Sun, Craig S. Charron, Janet A. Novotny, Bing Peng, Liangli Yu, Pei ChenAbstractBroccoli is a popular brassica vegetable and its consumption may decrease the occurrence of cancer in certain populations. To gain insight into the metabolites that may induce physiological responses to broccoli intake, a non-targeted metabolomic approach and a targeted approach for analysis of glucosinolate metabolites were developed using high resolution accurate mass spectrometry. A human study was conducted in which 6 subjects consumed a single meal ...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 13 October 2019Source: Advances in Biological RegulationAuthor(s): Veronica Balatti, Carlo M. CroceAbstractWe established that loss of miR-15a/16–1 genes on chromosome 13q14 is the most common alteration in Chronic Lymphocytic Leukemia (CLL) and that miR-15/16 are crucial negative regulator of BCL-2, an antiapoptotic gene overexpressed in most CLLs and in many other malignancies. We have also shown that miR-15/16 target ROR1, a cell surface receptor for Wnt5a which can enhance growth/survival of CLL cells. Interestingly, ROR1 is expressed by many cancers, but not by normal adult tis...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
Publication date: 1 December 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 184Author(s): Maosheng Xu, Kunsong Zhang, Yubing Liu, Jie Wang, Ke Wang, Yuanqing ZhangAbstractThe treatment of cancer has always been a worldwide problem. The combination of chemotherapy and other therapies would be a promising therapy strategy. Photothermal therapy (PTT) does not cause serious side effects and has dual control of time and space, which was considered to be a good method for combination with chemotherapy. Here, we modified multifunctional nanosheets based on in-situ gold nanoparticles (Au NPs) grown molybdenum disulfide...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 13 October 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Chaonan Yang, Qingfu Guo, Yan Lu, Bin Zhang, Guangming NieABSTRACTA novel “signal-on” electrochemiluminescence (ECL) immunosensor is constructed by using Au nanoparticle/graphene quantum dots-poly(etherimide)-graphene oxide (AuNP/GQDs-PEI-GO) composite as a probe to detect prostate-specific antigen (PSA). GQDs and AuNP are modified onto the PEI-GO through amide bond and electrostatic interaction sequentially. Poly(indole-6-carboxylic acid)/flower-like Au nanoparticles (PICA/FGNs) composites with satisfactory co...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: Available online 13 October 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Kubra Bilici, Abdullah Muti, Alphan Sennaroğlu, Havva Yagci AcarAbstractSuperparamagnetic iron oxide nanoparticles (SPIONs) have been recently recognized as highly efficient photothermal therapy (PTT) agents. Here, we demonstrate, for the first time to our knowledge, dose and laser intensity dependent PTT potential of small, spherical, 3-aminopropyltrimethoxysilane coated cationic superparamagnetic iron oxide nanoparticles (APTMS@SPIONs) in aqueous solutions upon irradiation at 795 nm. Indocyanine gr...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
It will have a fully staffed emergency room, about 10 observation beds plus, in Hempfield's case, an AHN cancer center and other physician offices.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Abstract Next-generation sequencing of DNA and RNA obtained from liquid biopsies of cancer patients may reveal important insights into disease progression and metastasis formation, and it holds the promise to enable new methods for noninvasive screening and clinical decision support. However, implementing liquid biopsy sequencing protocols is challenged by capturing circulating tumor cells or cell-free tumor DNA from blood samples, by amplifying genomic DNA and RNA in a reliable and unbiased manner, and by extracting biologically meaningful signals from the noisy sequencing data. In this chapter, we discuss comput...
Source: Cell Research - Category: Cytology Authors: Tags: Recent Results Cancer Res Source Type: research
Conclusions As the intestinal mucosa surface constitutes the major surface of the body which is in direct contact with the outer environment, intestinal immune homeostasis must be accurately regulated. The interplay between commensal microbiota, intestinal stromal cells, and the mucosal immune system components should guarantee the intestinal homeostasis to avoid a sustained inflammation that could induce tissue damage. However, several factors can lead to inflammation through homeostasis breakdown. Figure 1 summarizes the main points that have been reviewed here. We have described what it is known so far about the role o...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Join us Tuesday evening, March 12th, at 8 pm EST/ 7 pm CST/6 pm MT/5 pm PT for my Undoctored SIBO Workshop: A 2-hour in-depth exploration of SIBO that I shall present via live video broadcast. The cost to attend is $55. An unprecedented number of people now have small intestinal bacterial overgrowth, SIBO, an intestinal condition that has reached epidemic proportions. SIBO causes or worsens numerous health conditions such as fibromyalgia, irritable bowel syndrome, ulcerative colitis, restless leg syndrome, ulcerative colitis and Crohn’s disease. If you have any of these conditions or have diabetes (typ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates Source Type: blogs
Join us Wednesday evening, February 6th, at 8 pm EST/ 7 pm CST/6 pm MT/5 pm PT for my Undoctored SIBO Workshop: A 2-hour in-depth exploration of SIBO that I shall present via live video broadcast. The cost to attend is $55. (I will also be giving a SIBO Workshop for Undoctored Inner Circle members on Tuesday, February 5th at the same time slot.) An unprecedented number of people now have small intestinal bacterial overgrowth, SIBO, an intestinal condition that has reached epidemic proportions. SIBO causes or worsens numerous health conditions such as fibromyalgia, irritable bowel syndrome, ulcerative colitis, and...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates bowel flora Inflammation microbiota probiotic silo small intestinal bacterial overgrowth undoctored Source Type: blogs
More News: Cancer | Cancer & Oncology | Colectomy | Colon Cancer | Colorectal Cancer | Crohn's Disease | Diverticular Disease | Drugs & Pharmacology | Gastroenterology | Inflammatory Bowel Disease | Pathology | Study | Ulcerative Colitis