Rolipram Attenuates Early Brain Injury Following Experimental Subarachnoid Hemorrhage in Rats: Possibly via Regulating the SIRT1/NF- κB Pathway.

In conclusion, these data suggested that rolipram exerts neuroprotective effects against EBI after SAH via suppressing neuroinflammation and reducing neuronal loss. The neuroprotective effects of rolipram were associated with regulating the SIRT1/NF-κB pathway. Rolipram could be a novel and promising therapeutic agent for SAH treatment. PMID: 29397536 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29397536?dopt=Abstract

Source: Neurochemical Research - February 3, 2018 Category: Neuroscience Authors: Peng Y, Jin J, Fan L, Xu H, He P, Li J, Chen T, Ruan W, Chen G Tags: Neurochem Res Source Type: research