Nuclear Medicine Applications in Pediatric Musculoskeletal Diseases: The Added Value of Hybrid Imaging

This article discusses the utility of standard nuclear medicine procedures as they apply to children with musculoskeletal disorders, focusing on the added value of and indications for SPECT/CT. Subsequently, we discuss the expanding role of positron-emitting agents in infection, trauma, and for the diagnosis, staging, and therapeutic response monitoring of children with malignant bone and soft tissue tumors. Differences between disease processes encountered in children as compared with adults are discussed; developmental variants that can, but should not, be confused with disease are illustrated. The need for pediatric-specific protocols is addressed. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Seminars in Musculoskeletal Radiology - Category: Radiology Authors: Tags: Review Article Source Type: research

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Publication date: March 2019Source: International Journal of Paleopathology, Volume 24Author(s): Ileana Micarelli, Robert R. Paine, Mary Anne Tafuri, Giorgio ManziAbstractAn examination of an adult male buried from the post-classical necropolis of La Selvicciola (Viterbo, Latium, Italy; 4th–6th centuries AD) revealed a series of skeletal lesions. The lesions, both proliferative and lytic, ranging in size from small (around 0.01 mm) to extensive (up to 16.00 mm) pits, occurred at multiple sites. A holistic approach assessed lesion type, frequency and location in a differential diagnosis, which included myeloma,...
Source: International Journal of Paleopathology - Category: Pathology Source Type: research
ConclusionsWhen CNBO is refractory to treatment with anti-inflammatory drugs, intravenous pamidronate can be an alternative. Anti-TNF drugs can be considered in patients who fail with pamidronate, as can agents associated with other autoimmune conditions.ResumenIntroducciónLa osteomielitis multifocal crónica recurrente es una inflamación ósea aséptica poco frecuente en pediatría cuyo abordaje y tratamiento no está estandarizado.MétodosEstudio descriptivo retrospectivo de menores de 14 años a quienes se diagnosticó osteomielitis crónica no bacteria...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
We report a case of an otherwise healthy 12-year old boy, who developed an orbital subperiosteal abscess and paranasal sinusitis with concomitant septic arthritis of the left hip and osteomyelitis. We highlight the importance of repeat assessment of affected sites of infection, despite an overt, local infection of a primary site in an immunocompetent host. This is the first report of concurrent orbital subperiosteal abscess and left hip septic arthritis in literature.中文摘要化膿性關節炎是一種外科急症,可導致較高的發病率與死亡率,尤其在診斷延誤時。我們報道一例12歲男孩...
Source: Journal of Orthopaedics, Trauma and Rehabilitation - Category: Orthopaedics Source Type: research
ConclusionSupercharging the cancellous bone graft with bone marrow granulocytes precursors protect the site of infected non-union from recurrence of infection and bone resorption of the graft.
Source: International Orthopaedics - Category: Orthopaedics Source Type: research
CONCLUSIONThe angled joint resulting from this technique created a relatively normal permanently bent PIP joint.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionA thorough medical examination with further diagnostic work-up is most important inS. aureus blood stream infection to identify and eradicate the portal(s) of entry, to rule out endocarditis, to search for spinal abscesses, osteomyelitis or spondylodiscitis. Adherence to management guides for clinicians must be of major importance to achieve optimal quality of clinical care, and thus improve patient outcome.
Source: Infection - Category: Infectious Diseases Source Type: research
In conclusion, Masquelet induced membrane technique is effective for the treatment of large bone defects in rats after traumatic osteomyelitis. This technique significantly shortens the treatment cycle. The surgical procedure is simple, and the incidence of postoperative complications is low. PMID: 30214526 [PubMed]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Publication date: October 2018Source: Journal of Comparative Pathology, Volume 164Author(s): D. Walker, J. Gibbons, J.D. Harris, C.S. Taylor, C. Scott, G.K. Paterson, L.R. MorrisonSummaryYersinia pseudotuberculosis and Yersiniaenterocolitica are ubiquitous pathogens with wildlife and domestic animal reservoirs. Outbreaks of ‘non-plague’ yersiniosis in man and non-human primates are reported frequently (including zoological specimens and research breeding colonies) and are usually characterized by enteritis, mesenteric lymphadenitis and occasionally organ abscessation. In people, non-septic reactive arthrit...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
Publication date: Available online 11 August 2018Source: Orthopaedics &Traumatology: Surgery &ResearchAuthor(s): Gaoyang Chen, Bo Liu, He Liu, Hanyang Zhang, Kerong Yang, Qingyu Wang, Jianxun Ding, Fei ChangAbstractBackgroundAntibiotics impregnated calcium phosphate cement (CPC) has emerged as a local treatment of osteomyelitis. However, there is no study investigating the optimal concentrations of vancomycin (VCM) included in CPC to obtain prolonged drug release (≥ 8 weeks) and also with enough compressive strength (> the normal cancellous bone, 11 MPa) for osteomyelitis therapy. Therefore, we...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
Abstract The rheumatic diseases, which include systemic lupus erythematosus, rheumatoid arthritis, Beh çet's disease, scleroderma, and ankylosing spondylitis, are characterized by involvement of connective tissue, with multiple manifestations. In those diseases, there can be involvement of the peripheral or central nervous system, and that involvement can be primary, presenting as a major feature of the clinical presentation, or secondary, as an effect of the drugs used in order to control a given disease or its complications. Knowledge of the wide variety of imaging findings is crucial to the diagnosis of a rheumat...
Source: Radiologia Brasileira - Category: Radiology Source Type: research
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