Whole-body MRI gains momentum for oncology cases

Whole-body MRI is an emerging clinical tool for accurate and early assessment...Read more on AuntMinnie.comRelated Reading: Multiparametric MRI can help avoid renal mass biopsies MRI confirms prostate cancer with lower dose of GBCA Biomarker test could direct MRI use for prostate cancer Is ferumoxytol the alternative to gadolinium MRI agents? Short breast MRI protocol works for cancer detection
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Condition:   Metastatic Castration Resistant Prostate Cancer (mCRPC) Intervention:   Diagnostic Test: WB-MRI Sponsor:   Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Prostate Cancer;   Stereotactic Body Radiation Therapy Interventions:   Radiation: SBRT;   Radiation: STANDARD OF CARE Sponsor:   Grupo de Investigación Clínica en Oncología Radioterapia Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Findings herein unveil novel DNA-PK partners, substrates, and function in PCa. The role of DNA-PK impacts glycolysis through direct interaction with glycolytic enzymes and modulation of enzymatic activity. These events support energy production that may contribute to generation and/or maintenance of DNA-PK-mediated aggressive disease phenotypes.PMID:35078861 | DOI:10.1158/1078-0432.CCR-21-1846
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Source Type: research
Genome Med. 2022 Jan 25;14(1):9. doi: 10.1186/s13073-022-01011-3.ABSTRACTBACKGROUND: With over 350,000 estimated deaths worldwide in 2018, prostate cancer (PCa) continues to be a major health concern and a significant cause of cancer-associated mortality among men. While cancer in general is considered a disease of the human genome, there is a growing body of evidence suggesting that changes to the healthy microbiota could play a vital role in cancer development, progression, and/or treatment outcome.METHODS: Using a metatranscriptomic approach, we annotated the microbial reads obtained from total RNA sequencing of 106 pro...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Source Type: research
Genome Med. 2022 Jan 25;14(1):8. doi: 10.1186/s13073-021-01009-3.ABSTRACTBACKGROUND: Circular RNAs (circRNAs) constitute a largely unexplored source for biomarker discovery in prostate cancer (PC). Here, we characterize the biomarker potential of circRNAs in PC, where the need for novel diagnostic and prognostic tools to facilitate more personalized management is pressing.METHODS: We profiled the transcriptomic landscape of circRNAs in PC by total RNA sequencing of 31 adjacent-normal and 143 tumor samples from localized (radical prostatectomy (RP)) and metastatic PC patients (cohort 1, training). Diagnostic and prognostic ...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSIONS: Findings herein unveil novel DNA-PK partners, substrates, and function in PCa. The role of DNA-PK impacts glycolysis through direct interaction with glycolytic enzymes and modulation of enzymatic activity. These events support energy production that may contribute to generation and/or maintenance of DNA-PK-mediated aggressive disease phenotypes.PMID:35078861 | DOI:10.1158/1078-0432.CCR-21-1846
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Source Type: research
J Contemp Brachytherapy. 2021 Dec;13(6):605-614. doi: 10.5114/jcb.2021.112110. Epub 2021 Dec 30.ABSTRACTPURPOSE: To report on rectal dosimetry and toxicity outcomes in men with prostate cancer (PCa) treated with iodine-125 low-dose-rate brachytherapy (LDR-BT) with or without polyethylene glycol hydrogel (HS) or hyaluronic acid (HA) rectal spacer (RS) insertion.MATERIAL AND METHODS: Seventy consecutive men treated with LDR-BT between December 2017 and July 2019 were included in this study, including twenty-eight (40%) men who had RS insertion according to the preference of referring urologist, compared to a group of forty-t...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
Conclusions: As ETD measurements incremented, the risk of large tumors extending beyond the prostate increased accordingly, and patients with lower ET levels were more likely to occult UD. The influence of ETD on PCa biology should be addressed by prospective studies.Urol Int
Source: Urologia Internationalis - Category: Urology & Nephrology Source Type: research
Men with a genetic fault called BRCA2 have double the risk of developing prostate cancer, a study found. A third of men who have the mutation will be diagnosed with this cancer by the age of 85.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionAccording to a combination of quantitative scores from nuclear medicine doctors and evaluations with multiple image indicators, the synthesis of FDPET images based on MRI priors using and 50%-dose PET images did not affect the clinical diagnosis of prostate cancer. Prostate cancer patients can undergo 68 Ga-PSMA prostate PET/MRI scans with radiation doses reduced by up to 50% through the use of deep learning methods to synthesize FDPET images.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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