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The Growing Glaucoma Drug Landscape: Ophthalmology Times

(MedPage Today) -- Also, should we test new policies like we test new drugs?
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news

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Authors: Kwon J, Sung KR Abstract PURPOSE: To evaluate outcomes and factors associated with surgical failure in patients who underwent combined phacoemulsification and Ahmed glaucoma valve (AGV) implantation. METHODS: This retrospective and longitudinal study enrolled 40 eyes (38 patients) that underwent combined phacoemulsification and AGV implantation. Visual acuity, intraocular pressure (IOP), and number of antiglaucoma medications were evaluated preoperatively and postoperatively. Complete success was defined as a last follow-up IOP of 6 to 21 mmHg without medication, qualified success as an IOP of 6 to 21 ...
Source: Korean Journal of Ophthalmology : KJO - Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research
Authors: Amagasaki K, Nagayama M, Watanabe S, Shono N, Nakaguchi H Abstract Microvascular decompression (MVD) is widely accepted as an effective surgical method to treat trigeminal neuralgia (TN), but the risks of morbidity and mortality must be considered. We experienced a case of acute angle-closure glaucoma attack following MVD for TN in an elderly patient, considered to be caused by lateral positioning during and after the surgery. A 79-year-old female underwent MVD for right TN in the left lateral decubitus position, and TN disappeared after the surgery. Postoperatively, the patient tended to maintain the left...
Source: Neurologia Medico-Chirurgica - Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
Authors: Zhu J, Chen L, Qi Y, Feng J, Zhu L, Bai Y, Wu H Abstract Purpose: To investigate the neuroprotective effects of scutellarin, an active component of the multifunctional traditional Chinese herb Erigeron breviscapus (vant.) Hand.-Mazz. (EBHM), which has been used as a neuroprotective therapy for cerebrovascular diseases. We performed the experiments using in vitro and in vivo models of retinal neurodegeneration. Methods: In the in vitro experiments, we exposed BV-2 cells to low oxygen levels in an incubator for 24 and 48 h to generate hypoxia models. We then treated these cells with scutellarin at concen...
Source: Molecular Vision - Category: Molecular Biology Tags: Mol Vis Source Type: research
In conclusion, MSC-derived exosomes represent potentially new therapeutic agents in the therapy of degenerative and inflammatory ocular diseases. PMID: 29774506 [PubMed - as supplied by publisher]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
CONCLUSIONS: Upregulation of MEG3 is involved in the pathogenesis of glaucoma through promoting apoptosis of retinal ganglion cells, the mechanism of which may be related to the enhanced autophagy levels. PMID: 29771403 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
With great interest we read the article “Comparison of changes in mGCIPL thickness between medically and surgically treated eyes with advanced glaucoma,” by Inuzuka and associates,1 published in your esteemed journal in March. The research question of change in ganglion cell thickness over a long follow-up is important. The article ha s tried to bridge the gaps in knowledge in this field and has definitely added to the limited literature available; however, the following are our observations.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Correspondence Source Type: research
This article reviews evidence from the literature suggesting that primary open angle glaucoma (POAG) represents a group of heterogeneous diseases with varying clinical features rather than a single disease.Recent FindingsA growing body of evidence has been made available recently indicating that POAG behaves differently in different subpopulations. Although normal tension glaucoma has long been regarded as a diagnosis distinct from POAG, a considerable degree of overlap exists in their pathophysiology and clinical characteristics and suggests that intraocular pressure alone is not a reliable means of separating POAG into d...
Source: Current Ophthalmology Reports - Category: Opthalmology Source Type: research
ConclusionsSS-PERG adaptation accounts for a sizeable portion of the within-test variability. As it has robust SNR, sufficient test –retest variability, and is altered in disease, it may have physiological and clinical significance. This study suggests that SS-PERG protocols should include adaptation in addition to SS-PERG amplitude and phase/latency.
Source: Documenta Ophthalmologica - Category: Opthalmology Source Type: research
The objective of this study was to measure the mean central corneal thickness of different sub types of glaucoma and ocular hypertension of patients attending Menelik Hospital.Participants and Methods: A cross sectional comparative hospital-based study was carried out at the glaucoma clinic of Menelik ΙΙ Hospital to assess the pattern of central corneal thickness of patients with different subtypes of glaucoma from 01 May 2014 to 30 August 2014. Central corneal thickness was determined by taking average of six measurements using ultrasonic Pachymetry. All consecutive open angle glaucoma patient s and age matched ...
Source: Ethiopian Journal of Health Development - Category: African Health Source Type: research
Authors: Sachdev N, Aquino MC, Loon SC, Chan YH, Chew P, Koh V Abstract Background: To evaluate the outcome and complications of transscleral suture-fixated posterior chamber intraocular lens (PCIOL) implantation combined with Ahmed glaucoma valve (AGV) surgery in Asian eyes. Design: This was a retrospective study that included 22 eyes from 22 participants. The surgeries were performed at Singapore's National University Hospital. Participants underwent an Ahmed tube surgery, together with transscleral suture-fixated posterior chamber intraocular lens. Main Outcome Measures: Complete success was defined as 6...
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
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