The Growing Glaucoma Drug Landscape: Ophthalmology Times
(MedPage Today) -- Also, should we test new policies like we test new drugs?
We appreciate the interest in our manuscript and the comments raised by the readers. The authors of the letter suggest that axial length and disc size differences between control and glaucoma subjects in our study, if they exist, are possible confounding factors regarding the discriminative ability of macular and peripapillary spectral-domain OCT parameters and may jeopardize the conclusions.
We read with great interest the article by Akagi et al1 exploring the effects of disc hemorrhage (DH) on the progression of retinal nerve fiber layer (RNFL) thinning in glaucoma. They found that the rates of RNFL thinning were faster in DH quadrants after DH, and that intensification treatment has a beneficial effect.1 However, we have some questio ns. First, in this study, the authors found that the treatment intensification, visual field mean deviation, and difference in intraocular pressure before and after DH will have an effect on the global RNFL slope values.
CONCLUSIONS: In this pilot study, a quantitative difference was found in the protein expression of humor among patients with glaucoma, there being 27 proteins unique to patients with glaucomatous disease. PMID: 29439810 [PubMed - as supplied by publisher]
Guest: David Huang, MD, PhD Weeks Professor of Ophthalmic Research Casey Eye Institute Oregon Health &Science University Portland, OR
The thick and thin of the central corneal thickness in glaucoma, Published online: 15 February 2018; doi:10.1038/s41433-018-0033-3The thick and thin of the central corneal thickness in glaucoma
(MedPage Today) -- Also, understanding glaucoma on a cellular level
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Many studies have investigated the clinical benefits of Ologen for trabeculectomy. However, its benefits for Ahmed glaucoma valve (AGV) implantation have not been investigated as extensively. The aim of this s...
AbstractRho-associated protein kinase (ROCK), a ubiquitously expressed signaling messenger and downstream effector of Rho, is activated by several bioactive factors in the aqueous humor (AH). Rho-ROCK signaling regulates a wide spectrum of fundamental cellular events, including cell adhesion, motility, proliferation, differentiation, and apoptosis. Previous studies, including our own, found that ROCK inhibitor lowers intraocular pressure (IOP) via a direct effect on the conventional AH outflow pathway, by regulation of contractile properties, fibrotic activity, and permeability of the trabecular meshwork (TM) and Schlemm &...
Is trabeculectomy a good option for patients with increased IOP after failure of glaucoma drainage device surgery?Medscape Ophthalmology