Corneal Optical Changes Associated with Induced Edema in Fuchs Endothelial Corneal Dystrophy

In this study, we determined changes in corneal optical properties associated with induced corneal edema. Methods: Twenty-three phakic eyes (23 participants) with FECD (grades 1–6, modified Krachmer scale) and 8 normal eyes (8 participants) were examined by Scheimpflug photography. Central corneal thickness, high-order aberrations from anterior and posterior corneal surfaces, and backscatter from the anterior, mid-, and posterior cornea were determined from the Scheimpflug images. A low-oxygen permeable contact lens was placed on the eye, and eyes were closed for 2 hours, after which the lens was removed and Scheimpflug photography was repeated for up to 5 hours to determine changes in backscatter and high-order aberrations. Results: Corneas swelled by 10% [95% confidence interval (CI), 9–10]. Backscatter from the anterior cornea increased by 416 scatter units (SU, 95% CI, 344–488; P
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research