A Macrophage Colony-Stimulating Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence

γδ T cell frequency increases late during mouse and human malaria. Mamedov et al. show that oligoclonal TRAV15N-1 (Vδ6.3) γδ T cells expand across various tissues and prevent late-stage parasitemic recurrence. These protective γδ T cells exhibit a distinct transcriptional profile that inc ludes abundantly expressed M-CSF, which protects against Plasmodium recurrence.
Source: Immunity - Category: Allergy & Immunology Authors: Tags: Article Source Type: research