m-Trifluoromethyl-diphenyl diselenide promotes resilience to social avoidance induced by social defeat stress in mice: Contribution of opioid receptors and MAPKs

Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Suzan Gonçalves Rosa, Ana Paula Pesarico, Cristina Wayne Nogueira Depressive symptoms precipitated by stress are prevalent in population. In experimental models of social stress, endogenous opioids mediate different aspects of defensive and submissive behaviors. The present study investigated the opioid receptors, mitogen-activated protein kinase (MAPKs) and protein kinase B (Akt) contribution to m-trifluoromethyl-diphenyl diselenide [(m-CF3-PhSe)2] effects on social avoidance induced by social defeat stress (SDS). Adult Swiss mice were subjected to SDS and treated with (m-CF3-PhSe)2 (5 to 25mg/kg) for 7days. After that, the mice performed locomotor and social avoidance tests. The opioid receptors, MAPKs and Akt protein contents were determined in the prefrontal cortical samples of mice. Firstly, the mice were segregated in susceptible or resilient subpopulation based on their social avoidance induced by stress. (m-CF3-PhSe)2 (25mg/kg) was effective against the stress-induced social avoidance and improved social interaction behavior in mice. SDS increased the μ and κ protein contents but reduced those of δ opioid receptors in susceptible mice. Resilient and (m-CF3-PhSe)2-treated mice had no alteration in the levels of opioid receptors. Moreover, (m-CF3-PhSe)2 was effective against the increase of c-Jun N-terminal kinase (JNK) and the decrease of ...

Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research