Effects of calcium dobesilate on Nrf2, Keap1 and HO-1 in the lenses of D-galactose-induced cataracts in rats.
This study investigated the effects of calcium dobesilate on Nrf2, Keap1 and HO-1 in the lenses of D-galactose-induced cataracts in rats. Thirty Sprague-Dawley rats were randomly divided into three groups: a blank control group, a model control group and a model administration group. A normal diet was given to the rats in the blank control group and the rats with D-galactose-induced cataracts of the model control group. Calcium dobesilate was also given to the rats with D-galactose-induced cataracts of the model administration group. A slit lamp microscope was used to check the degree of lens opacity. RT-PCR and western blot analysis were used to detect the mRNA and protein expression of Nrf2, Keap1 and HO-1 in the lenses of the three groups. There was a significant difference in the degree of lens opacity among the three groups (P
Publication date: Available online 21 February 2019Source: Nitric OxideAuthor(s): Mauricio A. Retamal, Viviana P. Orellana, Nicolás J. Arévalo, Cristóbal G. Rojas, Rodolfo J. Arjona, Constanza A. Alcaíno, Wendy González, Jonathan G. Canan, Rodrigo Moraga-Amaro, Jimmy Stehberg, Luis Reuss, Guillermo A. AltenbergAbstractUnder normal conditions, connexin (Cx) hemichannels have a low open probability, which can increase under pathological conditions. Since hemichannels are permeable to relatively large molecules, their exacerbated activity has been linked to cell damage. Cx46 is highly expres...
Conclusions:Regular ophthalmologic examinations are recommended dueto the prevalence of clinical ocular abnormalities in HD patients.Keywords:Diabetic retinopathy, eye disease, kidney disease, kidney failure, renal dialysis
ConclusionsRisk factors for persistent iritis after cataract surgery include being diabetic, of African American racial background, and pupil expansion device use. These patients can be better informed of the higher risk of prolonged inflammation in their post-operative course, and peri-operative management can be tailored accordingly.
We appreciate the interest of Drs Grzybowski and Adamiec-Mroczek in our article.1 They point out that combination therapy with corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs) may have beneficial effects in the prevention of pseudophakic cystoid macular edema (PCME), but these effects seem to be limited to healthy patients and diabetic patients without retinopathy, with already a low incidence of PCME.2 In our study, the relative risk for PCME was not increased among diabetic patients without retinal complications and on the optimal glycemic target with any of the anti-inflammatory medications used.
CONCLUSION: In our large observational study, use of ACEI was not associated with an altered risk of cataract. PMID: 30733210 [PubMed - as supplied by publisher]
Conditions: Diabetic Macular Edema; Cataract Interventions: Drug: Bevacizumab; Drug: Ranibizumab; Drug: Aflibercept; Drug: Ozurdex Sponsors: Bay Area Retina Associates; Allergan Recruiting
This study analyzed 86 pairs of eyes of 86 patients. All groups were statistically simi lar in age and sex, but the total antioxidant capacity was lowest in patients with proliferative diabetic retinopathy. Moreover, the total oxidant status and levels of vascular endothelial growth factor and interleukin-6 were found to slightly increase according to the retinopathy status. Conclusio n: Oxidative stress, interleukin-6, and vascular endothelial growth factor in the aqueous humor seem to play important roles in the pathogenesis of diabetic retinopathy, especially in the proliferative type.RESUMO Objetivo: Procurou-se compar...