Sperm count and motility are quantitatively affected by functional polymorphisms of HTR2A, MAOA and SLC18A

Publication date: Available online 2 February 2018 Source:Reproductive BioMedicine Online Author(s): Miriam Cortés, Jose-Luis Royo, Arturo Reyes-Palomares, Ana M. Lendínez, Maximiliano Ruiz-Galdón, Armando Reyes-Engel Spermatozoa and neurones share similar membrane characteristics and features. Associations of multiple polymorphisms traditionally related to neurotransmission were investigated. Infertile men were grouped into controls with normospermia (n = 182) and idiopathic infertile men with asthenozoospermia (n = 103), and analysed as a case-control study and as a quantitative association of each genotype. Ten neurotransmission-associated genetic variants were mapped by SNP analysis using quantitative polymerase chain reaction with TaqMan probes. Men with HTR2A rs6313 had a higher risk of asthenozoospermia (OR = 2.14; P = 0.04). MAOA rs3788862 G carriers displayed an increased risk of asthenozoospermia (OR = 2.29; P = 0.02). The SLC18A1 rs1390938 G allele was more frequent among such cases (0.75 versus 0.87; P < 0.01 and P < 0.01 for Armitage trend test); for SLC18A1 rs2270641 P = 0.02 (case-control frequency) and P = 0.01 (Armitage trend test). MAOA rs3788862 was correlated with sperm motility (Spearman ρ = 0.14; P = 0.02); SLC18A1 rs1390938 was correlated with sperm count and motility (Spearman ρ = 0.20; P < 0.01). Gene polymorphisms of HTR2A, MAOA and SLC18A1, related to neurotransmission, are individually associated with asthenoz...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

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Publication date: Available online 16 November 2019Source: Life SciencesAuthor(s): Yalda Jahanbani, Soudabe Davaran, Maryam Ghahremani-Nasab, Leili Aghebati-Maleki, Mehdi YousefiAbstractTissue engineering and the use of scaffolds have shown high therapeutic potentialities about male and female infertility. Nowadays, many couples are suffering from infertility problems. There are different causes for infertility including chemotherapy (for male and female), uterine injuries, and intrauterine adhesions. Extra-cellular matrix in tissue engineering provides a supportive medium for blood or lymphatic vessels making it a suitabl...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 15 November 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Keisuke Tanaka, Leah Mayne, Akram Khalil, David Baartz, Lars Eriksson, Sally-Anne Mortlock, Grant Montgomery, Brett McKinnon, Akwasi A AmoakoAbstractEndometriosis affects a large proportion of women during their reproductive years and is associated with pain and infertility, also affecting psychological wellbeing and quality of life. The pathogenesis of the disease remains unclear, although it is believed to be multifactorial. The endocannabinoid system (ECS) consists of a number of l...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 16 November 2019Source: Reproductive BioMedicine OnlineAuthor(s): Shuang Yuan, Yichao Qiu, Yuanyuan Xu, Hongjing WangAbstractIncreasing evidence shows that HPV infection affects reproductive health and fertility, although its impact on female fertility has not been thoroughly studied. We conducted a meta-analysis of 12 studies including 15450 female subjects that compared HPV prevalence between the infertile and general population, and evaluated the association between HPV positivity and female infertility. Seven case-controlled studies on 3581 participants reported indiscriminate genotyp...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Tags: Amenorrhea and Infertility Source Type: blogs
We report a case of a 36-year-old woman with type 2 diabetes mellitus and a one-year of primary infertility. Following oral ovulation induction cycles and IUI, diagnosis of heterotopic cervical pregnancy was made by ultrasonography at 7.4 weeks of gestation. Laser ablation of the cervical pregnancy was performed achieving adequate homeostasis at the implantation site and preserving the intrauterine pregnancy. A healthy infant was delivered at 36 0/7 wks by cesarean-section.Laser ablation is a minimally invasive procedure that appears to lead to successful outcomes in treatment of heterotopic cervical pregnancy.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
AbstractPurpose of ReviewThis review highlights the role of imaging in the diagnosis and management of reproductive disorders. The additional information that imaging studies can contribute to reproductive medicine is emphasized, including the role of pelvic ultrasonography (US, including sonohysterography and contrast-enhanced hysterosalpingosonography), hysterosalpingography (HSG), and magnetic resonance imaging (MRI) of the female reproductive tract. In addition, the implications of congenital causes of infertility on the urinary tract in females are reviewed.Recent Findings SummaryWhile the evaluation of infertility in...
Source: Current Urology Reports - Category: Urology & Nephrology Source Type: research
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