Blood Test for Alzheimer ’s? CTE in Woodpeckers; Comeback for NGF

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Source: MedPage Today Primary Care - Category: Primary Care Source Type: news

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Phys. Chem. Chem. Phys., 2018, Accepted Manuscript DOI: 10.1039/C8CP01631C, PaperYibo Jin, Yunxiang Sun, Jiangtao Lei, Guanghong Wei Alzheimer's disease (AD) is associated with the aggregation of amyloid-[small beta] (A[small beta]) peptides into toxic fibrillar aggregates. Finding effective inhibitors of A[small beta] aggregation is a crucial step for the development of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
In a recent paper, researchers provided evidence to suggest that the risk factors associated with cardiovascular decline with age interact with amyloid-β in the brain to accelerate cognitive decline. Having more of both produces a worse prognosis, which is not all that surprising. This is the case in many areas of aging and age-related disease: forms of damage and dysfunction interact with one another, making consequences worse than would be the case if they were independent of one another. This is one of the reasons why aging is an accelerating process, starting off slow and picking up pace ever more rapidly as the d...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Alzheimer’s disease now affects approximately 5.5 million Americans, and it is estimated that 16 million people will be living with the disease by the year 2050. To put this in perspective, while deaths from heart disease have decreased by 14 percent since 2000, deaths from Alzheimer’s disease have increased by 89%. It is interesting to note that 35 percent of caregivers (family and friends) of Alzheimer’s or other dementia patients report that their own health has declined compared to 19 percent of caregivers of older people with no dementia. This illness can cause intense suffering not only for those w...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Alzheimer's Brain and Behavior Memory and Perception Research Alzheimer's disease Episodic memory Memory Loss Source Type: blogs
While a link has previously been shown between the APOE epsilon 4 genetic variant and neuropathology, new research suggests it also elevates risk for psychiatric symptoms after TBI.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
CONCLUSIONS: The prevalence and incidence of dementia increase exponentially from the age of 65 onwards. As a consequence of the progressive ageing of the population and the increase in life expectancy, the number of cases of dementia will rise in the coming decades. Recent studies point to a slight drop in the accumulated risk of dementia adjusted by age groups and sex over the last few decades in some countries. It is possible that by means of primary prevention strategies implemented upon the known risk factors for dementia the burden of dementia on public health will diminish in the future. PMID: 29790571 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
After a series of high-profile drug failures, researchers are being forced to question their primary hypothesis of Alzheimer's disease.
Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news
Because of their low levels of expression and the inadequacy of current research tools, CB2 cannabinoid receptors (CB2R) have been difficult to study, particularly in the brain. This receptor is especially releva...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
Publication date: Available online 18 May 2018 Source:Journal of Molecular Biology Author(s): Darcy S. Davidson, Anne M. Brown, Justin A. Lemkul Pathological aggregation of amyloid-forming proteins is a hallmark of a number of human diseases, including Alzheimer's, type 2 diabetes, Parkinson's, and more. Despite having very different primary amino acid sequences, these amyloid proteins form similar supramolecular, fibril structures that are highly resilient to physical and chemical denaturation. To better understand the structural stability of disease-related amyloids and to gain a greater understanding of factors that st...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 18 May 2018 Source:Journal of Molecular Biology Author(s): Martina Radli, Stefan G.D. Rüdiger The molecular chaperone Hsp90 is involved in the folding, maturation and degradation of a large number structurally and sequentially unrelated clients, often connected to serious diseases. Elucidating the principles of how Hsp90 recognises this large variety of substrates is essential for comprehending the mechanism of this chaperone machinery, as well as it is a prerequisite for the design of client specific drugs targeting Hsp90. Here, we discuss the recent progress in understanding the s...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Conclusion Deficits in mitochondrial function, dynamics, and antioxidant capabilities putatively mediated through sub-optimal AMPK/SIRT/PGC-1α signaling, are involved in the development of early sub-clinical neurodegeneration in the cortex under diabetic conditions.
Source: Molecular and Cellular Neuroscience - Category: Neuroscience Source Type: research
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