Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines.

CONCLUSION: Mutations in exon 1 of NUDT15 also affect thiopurine-induced leukopenia in patients with IBD. To discuss thiopurine-induced leukopenia in more detail, investigation of SNPs in both exon 1 and exon 3 of NUDT15 is needed.
PMID: 29398872 [PubMed - in process]

Source: World Journal of Gastroenterology : WJG - January 28, 2018 Category: Gastroenterology Authors: Kojima Y, Hirotsu Y, Omata W, Sugimori M, Takaoka S, Ashizawa H, Nakagomi K, Yoshimura D, Hosoda K, Suzuki Y, Mochizuki H, Omata M Tags: World J Gastroenterol Source Type: research