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Flortaucipir-PET could lead in early Alzheimer's detection

PET scans with the novel radiotracer flortaucipir may provide more valuable...Read more on AuntMinnie.comRelated Reading: Novel PET tracer helps diagnose concussed patients PET with tau agent sheds light on Alzheimer's disease Novel PET combination awarded SNMMI Image of the Year SNMMI: PET shows tau may be Alzheimer's catalyst
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Healthy aging is associated with impairment in cognitive information processing. Several neuroimaging methods such as functional magnetic resonance imaging, positron emission tomography and near-infrared spectroscopy have been used to explore healthy and pathological aging by relying on hemodynamic or metabolic changes that occur in response to brain activity. Since electroencephalography (EEG) and magnetoencephalography (MEG) are able to measure neural activity directly with a high temporal resolution of milliseconds, these neurophysiological techniques are particularly important to investigate the dynamics of brain activ...
Source: Neuropsychobiology - Category: Psychiatry & Psychology Source Type: research
In this study, we sought to investigate 18F-flortaucipir binding patterns and their correlates in clinically-diagnosed bvFTD patients by comparing with results for Alzheimer ’s disease (AD) patients. We enrolled 20 bvFTD, 20 AD and 20 age-matched healthy subjects who underwent neuropsychological tests, magnetic resonance imaging, and tau positron emission tomography scans with 18F-flortaucipir.
Source: Neurobiology of Aging - Category: Neuroscience Authors: Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 16 February 2018 Source:The Lancet Neurology Author(s): Shu-Ying Liu, Daryl J Wile, Jessie Fanglu Fu, Jason Valerio, Elham Shahinfard, Siobhan McCormick, Rostom Mabrouk, Nasim Vafai, Jess McKenzie, Nicole Neilson, Alexandra Perez-Soriano, Julieta E Arena, Mariya Cherkasova, Piu Chan, Jing Zhang, Cyrus P Zabetian, Jan O Aasly, Zbigniew K Wszolek, Martin J McKeown, Michael J Adam, Thomas J Ruth, Michael Schulzer, Vesna Sossi, A Jon Stoessl Background Markers of neuroinflammation are increased in some patients with LRRK2 Parkinson's disease compared with individuals with idiopathic Parkinso...
Source: The Lancet Neurology - Category: Neurology Source Type: research
JoAnn Wooding is staring intently at the clear liquid dripping from a dark brown IV bag into her husband Peter’s arm. “Please be the drug, please be the drug,” she says. Married for more than 50 years, the Woodings are among the more than 5 million Americans who are facing Alzheimer’s disease, one of the most devastating diagnoses today. But instead of accepting the slow descent into memory loss, confusion and dementia, Peter–who has the disease–could be among the first to successfully stop that decline from happening. Peter, 77, is one of the 2,700 people around the world who are expect...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's Disease healthytime Longevity Source Type: news
The introduction of positron emission tomography (PET) tracers that can identify paired helical filaments of hyperphosphorylated tau (ie, neurofibrillary tangles) has been met with tremendous optimism in the field of Alzheimer disease (AD) research. For example, a search in PubMed indicates that the number of publications returned by a search of the words “tau PET” has increased from 39 in 2010 to more than 270 in the past 2 years, and tau PET scans are now being integrated into large observational and clinical trial studies. This optimistic spread of investigation is based on the expectation that these tracers...
Source: JAMA Neurology - Category: Neurology Source Type: research
In conclusion, most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflammaging. Together, immunosenescence and inflammaging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of gerontologists have chall...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Neuroinflammation has long been considered a potential contributor to neurodegenerative disorders that result in dementia. Accumulation of abnormal protein aggregates in Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies is associated with the activation of microglia and astrocytes into proinflammatory states, and chronic low-level activation of glial cells likely contributes to the pathological changes observed in these and other neurodegenerative diseases. The 18kDa translocator protein (TSPO) is a key biomarker for measuring inflammation in the brain via positron emission tomog...
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Adv Pharmacol Source Type: research
AbstractWe evaluated the performance of amyloid PET textural and shape features in discriminating normal and Alzheimer ’s disease (AD) subjects, and in predicting conversion to AD in subjects with mild cognitive impairment (MCI) or significant memory concern (SMC). Subjects from the Alzheimer’s Disease Neuroimaging Initiative with available baseline18F-florbetapir and T1-MRI scans were included. The cross-sectional cohort consisted of 181 controls and 148  AD subjects. The longitudinal cohort consisted of 431 SMC/MCI subjects, 85 of whom converted to AD during follow-up. PET images were normalized to MNI s...
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research
Abstract Small-molecule inhibitors that block the Keap1-Nrf2 protein-protein interactions are being intensely pursued as a new therapeutic strategy for oxidative stress-related diseases, such as cancer, diabetes, Alzheimer's disease, arteriosclerosis, inflammation and myocarditis. However, there are not enough studies on antioxidant treatments using small molecules in myocarditis. We herein provided a series of novel hydronaphthoquinones as the Keap1-Nrf2 interaction inhibitors targeting LPS-induced myocarditis both in vitro and in vivo. These compounds were designed through an in-silico fragment growing approach ...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Tags: Free Radic Biol Med Source Type: research
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