Neoplasia in Three Aye-Ayes (Daubentonia madagascariensis)

Publication date: February 2018 Source:Journal of Comparative Pathology, Volume 159 Author(s): A. Rodriguez Barbon, R. Cowen, C. Knott, K. Hughes, K. Allinson, C.V. Williams, A. Routh Tumours diagnosed in three aged captive aye-ayes (Daubentonia madagascariensis), held in two different institutions, are described. A cerebral glioblastoma was diagnosed based on histological and immunohistochemical findings in one of the animals following initial presentation with bilateral mydriasis, absent pupillary reflex, head tilt and ataxia. A second animal was humanely destroyed due to impaired locomotion associated with spondylosis and a post-mortem diagnosis of cholangiocarcinoma was made based on histology with further confirmation with immunohistochemical labelling for cytokeratin 7. A third aye-aye suffering from dental disease was diagnosed with an oral squamous cell carcinoma following an excisional biopsy from a non-healing wound in the lip. Due to progression of the neoplasia the animal was humanely destroyed and post-mortem examination revealed the presence on an additional unilateral phaeochromocytoma.
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research