Refining risk in diabetes and CAD with SPECT MPI: New insights and future challenges

Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research

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Conclusions: The 99mTc-HMPAO labeled leukocytes scintigraphy is a time consuming and complex procedure, but training, education and optimization makes this procedure viable with proven benefits for the patients.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibits Source Type: research
Conclusions: About 1 in 5 patients undergoing PET MPI are referred for coronary angiography within 90 days of testing, a rate greater than that reported for SPECT MPI, likely due to higher baseline risk of patients undergoing PET MPI testing. While referral rates for coronary angiography varied based on the presence or absence of prior documented clinical CAD and presence of test abnormalities, nearly 36% of patients with moderate-severe ischemia were not referred. Further work is needed to characterize why such patients are not referred for invasive evaluation to optimize the use of PET MPI in this high-risk population.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science Poster Session Source Type: research
1552Objectives: Diabetes mellitus (DM) is an independent risk factor for coronary artery disease (CAD). Early identification of CAD and prediction of cardiac events are essential for diabetic patients. The aim of our study was to evaluate the value of SPECT myocardial perfusion imaging (MPI) in early prediction cardiac events of diabetes. Materials and Methods: We reviewed cardiovascular outcomes (cardiac death or nonfatal MI and revascularization) of 1047 patients who were suspected with CAD and underwent SPECT-MPI. The mean interval of following up was 33.25±14.95(1~56)months. Patients were stratified into two gro...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science Poster Session Source Type: research
The objective of the present study is to investigate the predictive value of LVMD for long-term ACE after CABG in CAD patients by radionuclide myocardial imaging. Methods: From September 2013 to March 2016, 49 patients (44 males, 5 females, average age: (64±8) years) with CAD in the Third Affiliated Hospital of Soochow University were prospectively recruited. All patients underwent 99mTc-MIBI gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) and F-18-FDG positron emission tomography (PET) myocardial metabolic imaging to assess myocardial viability preoperatively and gated SP...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science Poster Session Source Type: research
1571Objectives: Cardiac 123I-metaiodobenzylguanidine (123I-MIBG) innervation scintigraphy with heart-to-mediastinum ratio (HMR) can be used to differentiate Parkinson Disease (PD) and Lewy Body Disease (LBD) from other parkinsonian syndromes. We assessed the HMR feasibility and reproducibility using cardiac scintigraphy with the simultaneous acquisition of 123I-MIBG and 99mTc-tetrofosmin. Methods: We included 26 patients (12 F, 14 M, aged 70 ± 11 years) with a clinical parkinsonian syndrome, without neuroleptic, myocardial infarction or diabetes. Cardiac dual isotope acquisition with 99mTc-tetrofosmin and 123I-MIBG ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science Poster Session Source Type: research
Conclusions:Patients with LVH had significantly more LVMD than the control group, even in absence of abnormal perfusion/scar, electrical dyssynchrony and preserved LVEF and increased gated LV mass was associated with increased incidence of LVMD. The patients with LVH showing LVMD may require aggressive management in spite of normal perfusion and adequate LVEF.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Technologist Poster Session Source Type: research
1341Objectives: Salivary gland damage is a common adverse effect of high dose radioiodine therapy for thyroid cancer. So far, less is known about possible salivary gland damages following low dose I-131 ablation (RIA) with rhTSH stimulation. The aim of this study was to investigate whether salivary gland damages is induced by low dose RIA for thyroid cancer. Methods: 59 patients with post-surgical papillary thyroid cancer (M/F 15/34, age:27-75yrs.), who were to undergo first time RIA with 30mCi of I-131, were enrolled. None of the patients had previous history of salivary gland disorders, diabetes, or collagen tissue disea...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrine/Neuroendocrine Posters Source Type: research
512Objectives: Radiomic analysis has witnessed significant activity especially in oncologic MRI, CT and PET, but remains to be thoroughly assessed in SPECT and/or cardiac imaging. Myocardial perfusion SPECT (MPS) is established for diagnosis of patients suspected with coronary artery disease (CAD). Meanwhile, coronary artery calcification (CAC) scoring is shown to offer added value in patients with negative MPS for identifying patients with significant CAD. Nonetheless, CAC scoring is not readily available in the community setting and is not currently reimbursed by CMS. We aimed to assess whether quantitation of heterogene...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: New Developments in SPECT Myocardial Perfusion Imaging Source Type: research
1624Objectives: To study on the application of 99mTc-DTPA orbital SPECT and investigate the clinical value of orbital CT measuring retrobulbar volume in the retrobulbar radiotherapy for Moderate-to-severe active TAO. Methods: 37 cases Moderate-to-severe active TAO were chosen in our hospital. All the cases were two eyes extruding. And 22cases were chosen to be the Radiotherapy group, who were received Orbital radiotherapy and poor curative effect with inject triamcinolone acetonide. We reviewed 15cases be injection group, who were heavy inflammatory response and were only inject with triamcinolone acetonide. Selected patie...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Outcomes/Infectious Disease/Pulmonary Posters Source Type: research
AbstractPurposeEpidemiologic studies have revealed that early life malnutrition increases later risk of metabolic diseases. The visceral adiposity index (VAI) is a novel sex-specific index that shows promise as a marker of visceral adipose dysfunction. We aimed to explore whether exposure to the Chinese famine between 1959 and 1962 during fetal and childhood periods was related to VAI in adulthood.MethodsOur data source was SPECT-China, a population-based cross-sectional study in East China. Overall, 5295 subjects from 16 sites were divided into fetal-exposed (1959 –1962), childhood-exposed (1949–1958), adolesc...
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
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