GSE94570 Identification of MELK-regulated genes in prostate cancer cells using next-generation sequencing

Contributors : Sarah Jurmeister ; Antonio Ramos-Montoya ; S érgio L Felisbino ; David E NealSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA cross-species analysis identified MELK as a potential therapeutic target in prostate cancer. To further elucidate the functional role of MELK in prostate cancer cells, we aimed to identify MELK-regulated genes. C4-2b cells were either treated with a small-molecule MELK inhibitor (OTSSP167), or transfected with siRNAs targeting MELK. Differentially expressed genes were identified using next-generation sequencing. Our results demonstrate that MELK promotes the expression of genes associated with tumour progression in prostate cancer cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research