Study of Tolerance, Biodistribution and Dosimetry of Fucoidan Radiolabeled by Technetium-99m

Condition:   Healthy Volunteer Intervention:   Drug: 99mTc-Fucoidan SPECT Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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AbstractAlzheimer ’s disease, Parkinson’s disease, prion diseases, schizophrenia, and multiple sclerosis are the most common nervous system diseases, affecting millions of people worldwide. The current scientific literature associates these pathological conditions to abnormal expression levels of certain proteins , which in turn improved the knowledge concerning normal and affected brains. However, there is no available cure or preventive therapy for any of these disorders. Proteogenomics is a recent approach defined as the data integration of both nucleotide high-throughput sequencing and protein mass spect ro...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
Conclusion: We found pulmonary inhalation-perfusion scintigraphy to be a useful tool for identifying a residual BPF, as well as being an alternative method of investigating BPFs and of monitoring the affected patients.Resumo Objetivo: Avaliar a cintilografia por inala ção-perfusão pulmonar como método alternativo de investigação e acompanhamento em pacientes com fístula broncopleural (FBP). Materiais e Métodos: Nove pacientes com FBPs foram tratados de forma endoscópica com o uso off label de um oclusor transcateter de defeito do septo interatrial e for am segu...
Source: Radiologia Brasileira - Category: Radiology Source Type: research
Authors: Marinescu I, Vasiliu O, Vasile D Abstract An intensively researched and yet poorly understood phenomenon, both at clinical and neurobiological level, is the determinism of treatment-resistant depression. Even more controversial are the stages of approaching therapeutically this pathology because there are no evidence-based recommendations stating that a pharmacological agent is superior to another, on medium and long-term. Due to the lack of "golden standard" approaches, physician's experience, therapeutic alliance and a close monitoring stand as the most useful good practices in the treatment of...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
Authors: Kuusk T, De Bruijn R, Brouwer OR, De Jong J, Donswijk M, Hendricksen K, Horenblas S, Jó┼║wiak K, Prevoo W, Valdés Olmos RA, Van Der Poel HG, Van Rhijn BW, Wit EM, Bex A Abstract OBJECTIVE: To investigate the rate of occult SN metastases, oncological outcome, and association of recurrence with the pattern of lymphatic tumour drainage in RCC. MATERIALS AND METHODS: A pooled RCC sub-group analysis was conducted of secondary endpoints from a published feasibility and a phase II prospective single-arm SN study to investigate oncological outcome. Patients with cT1-3 (
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
AbstractObjectiveA recently introduced single-photon emission computed tomography (SPECT), based on cadmium-zinc-telluride (CZT) detectors (D-SPECT), supports high energy resolution for cardiac imaging. Importantly, the high energy resolution may allow simultaneous dual-isotope (SDI) imaging (e.g., using Tc-99m and I-123). We quantitatively evaluated Tc-99m/I-123 SDI imaging by D-SPECT in comparison with conventional T1-201/I-123.Materials and MethodsEnergy resolution was measured as a percentage of the full width at half maximum (FWHM) for Tc-99m, I-123, and Tl-201. The impact of cross-talk and reconstructed image contras...
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Early consideration of seizures arising from the frontal operculum manifesting as nocturnal paroxysmal laryngospasm is critical, since the condition can go undiagnosed, resulting in considerable disruption in restorative sleep and daily function.
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: All Sleep Disorders, All Epilepsy/Seizures, Epilepsy semiology, SPECT in epilepsy Case Source Type: research
Blood loss from the gastrointestinal tract can be an acute and life-threatening event. For the treatment of gastrointestinal bleeding, it is important to accurately detect gastrointestinal bleeding and to loca...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Research article Source Type: research
AbstractBackgroundDetermining the risk of cardiovascular events is essential to optimize patient management.Methods and Results5842 individuals underwent SPECT  myocardial perfusion imaging (MPI) with 4.4 ± 1.2 years of follow-up. Models (the CRAX tool) were derived to predict the cumulative risk of death and acute myocardial infarction (AMI) at 1, 3, and 5 years using clinical and MPI variables. Predictors of AMI and death included age, number o f hospitalizations in the 3 years preceding MPI, and left ventricular ejection fraction (LVEF). Additional predictors of death w...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
Authors: Akbulut A, Kalayci S, Koca G, Korkmaz M PMID: 30507353 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Authors: Siniscalchi C, Gaibazzi N PMID: 30507298 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
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