The effects of bisphosphonate zoledronic acid in hepatocellular carcinoma, depending on mevalonate pathway

ConclusionsOur results indicated that ZOL prevented cell growth and metastasis based on direct antitumor effects in hepatoma cells. The use of ZOL could not only suppress the progression to bone metastatic lesions but also prevented growth of primary HCC.

Source: Journal of Gastroenterology and Hepatology - August 29, 2014 Category: Gastroenterology Authors: Yohji Honda, Shoichi Takahashi, Yizhou Zhang, Atsushi Ono, Eisuke Murakami, Niu Shi, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Nobuhiko Hiraga, Hiromi Abe, Hidenori Ochi, Michio Imamura, Hiroshi Aikata, Kazuaki Chayama Tags: Experimental Hepatology Source Type: research