First-line ribociclib plus letrozole in postmenopausal women with HR+  , HER2− advanced breast cancer: Tumor response and pain reduction in the phase 3 MONALEESA-2 trial

ConclusionRIB plus LET versus PBO plus LET is associated with earlier and more durable tumor response, greater degree of tumor shrinkage and pain reduction, and PFS benefit irrespective of TFI. These data further support RIB plus LET as a first-line treatment option for postmenopausal women with HR+  , HER2− ABC.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research

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ConclusionsHRQoL was consistently maintained from baseline in postmenopausal women with HR+, HER2 − advanced breast cancer receiving ribociclib plus letrozole and was similar to that observed in the placebo plus letrozole arm. Together with the improved clinical efficacy and manageable safety profile, these PRO results provide additional support for the benefit of ribociclib plus letrozole in this patient population.
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Purpose: Radiation therapy is an important treatment modality in the curative management of early stage breast cancer. With increasing cancer survivorship, late effects of cancer treatment have become increasingly relevant. Breast fibrosis is a common late effect following therapeutic irradiation which can potentially result in pain, poor cosmesis, and functional impairment. Randomized trials have suggested that radiation fibrosis may be reversible or preventable using a medication regimen of Pentoxifylline and Vitamin E. These clinical trials have shown excellent patient compliance and tolerability of this regimen, but it...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research
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