Tanzania:Doc Explains Colorectal Is a Worrisome Health Issue
[Daily News] WHILE national records cite cervical cancer as the second most troublesome disease in Tanzania behind breast cancer, the Aga Khan hospital has slotted colorectal cancer in the position.
Conclusion Alpelisib demonstrated a tolerable safety profile and encouraging preliminary activity in patients with PIK3CA-altered solid tumors, supporting the rationale for selective PI3Kα inhibition in combination with other agents for the treatment of PIK3CA-mutant tumors. PMID: 29401002 [PubMed - as supplied by publisher]
Conclusion In general, these incidence patterns were similar to those reported in neighboring countries, which suggests that the majority of cancer cases occurring in Addis Ababa are captured within this starting phase of the registry. However, our finding of colorectal cancer as the most commonly-diagnosed cancer in males is novel and requires further investigation.
The TFCP2/Grainyhead family of transcription factors is divided into two distinct subfamilies, one of which includes the Grainyhead-like 1-3 (GRHL1-3) proteins and the other consists of TFCP2 (synonyms: CP2, LSF, LBP-1c), TFCP2L1 (synonyms: CRTR-1, LBP-9) and UBP1 (synonyms: LBP-1a, NF2d9). Transcription factors from the TFCP2/TFCP2L1/UBP1 subfamily are involved in various aspects of cancer development. TFCP2 is a pro-oncogenic factor in hepatocellular carcinoma, pancreatic cancer and breast cancer, may be important in cervical carcinogenesis and in colorectal cancer.
Publication date: Available online 31 January 2018 Source:The Lancet Author(s): Claudia Allemani, Tomohiro Matsuda, Veronica Di Carlo, Rhea Harewood, Melissa Matz, Maja Nikšić, Audrey Bonaventure, Mikhail Valkov, Christopher J Johnson, Jacques Estève, Olufemi J Ogunbiyi, Gulnar Azevedo e Silva, Wan-Qing Chen, Sultan Eser, Gerda Engholm, Charles A Stiller, Alain Monnereau, Ryan R Woods, Otto Visser, Gek Hsiang Lim, Joanne Aitken, Hannah K Weir, Michel P Coleman Background In 2015, the second cycle of the CONCORD programme established global surveillance of cancer survival as a metric of the effectiveness of ...
Conclusions Focal uptake in the colon of 18F-FDG PET/CT has clinical relevance, especially when it is associated with morphological lesions on CT. As it may be a second tumor or a pre-malignant lesion, it is recommended that all focal uptake of the colon with or without abnormal CT be evaluated with endoscopy.
dul Kadir Pistachio (Pistacia vera L.) hulls (PVLH) represents a significant by-product of industrial pistachio processing that contains high amounta of phenolic and flavonoid compounds known to act as antioxidants. The current study was designed to evaluate the anti-tumor and anti-angiogenic potentials of PVLH extracts. The cytotoxic effects of hexane, ethyl acetate, methanol, and water PVLH extracts toward human colon cancer (HT-29 and HCT-116), breast adenocarcinoma (MCF-7), lung adenocarcinoma (H23), liver hepatocellular carcinoma (HepG2), cervical cancer (Ca Ski), and normal fibroblast (BJ-5ta) cells were assessed...
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This study examined whether screenings of breast cancer, cervical cancer, and colorectal cancer impact early-stage cancer incidence and mortality in Missouri.
Conclusion Smoking, infectious agents, and betel nut chewing appear to be important contributors to the burden of cancer in Guam. Earlier onset of cancer in Guam suggests earlier age of exposure to key risk factors and/or a more aggressive pathogenesis. Contrasting cancer patterns within Guam and between Guam and Hawaii underscore the potential influence of genes, lifestyle, and environmental factors on cancer development and progression.
Publication date: 15 December 2017 Source:Journal of Organometallic Chemistry, Volume 853 Author(s): Tabinda Fatima, Rosenani A. Haque, Muhammad Adnan Iqbal, Ashfaq Ahmad, Loiy Elsir Ahmed Hassan, Mohamad Taleb-Agha, Mohamed B. Khadeer Ahamed, A.M.S. Abdul Majid, Mohd. R. Razali Present study involves the synthesis and characterization of a newly designed tetrakis benzimidazolium salts, 1–5 and their respective tetra N-heterocyclic carbene (NHC) dinuclear silver(I) complexes, 6–10 with different terminal substituents that constructed from either cyclopentyl, benzyl, n-butyl, 2-methylene benzonitrile or n-decyl...