Kate Winslet saved my life: Brave mother delayed cancer treatment to save unborn daughter

A MOTHER who delayed crucial cancer treatment to have her baby is free of the disease after film stars Leonardo DiCaprio and Kate Winslet helped raise cash for her treatment. Gemma Nuttall, 29, was told she had an aggressive ovarian cancer after her first pre-natal scan, but she refused life-saving treatment as it would have killed her unborn child.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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ConclusionsThis case highlights the importance of recognizing gastrointestinal complications following chemotherapy and the need to be aware of the possibility of bowel perforation. Prompt surgical review and intervention must be requested in patients with acute abdominal pain and persistent gastrointestinal symptoms such as diarrhea and vomiting.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
CONCLUSIONS: Our results suggest that the antiproliferative effect of AN-152 can be detected even if only LHRH receptor isoforms are expressed. Our study also demonstrates the LHRH receptor-mediated uptake of AN-152 in DOX resistant OCM3DOX320 cells. Our experiments provide new insights into a potential targeted therapy of UM and give further details about the accumulation of AN-152 in hormone-independent DOX-resistant cells expressing splice variants of the LHRH receptors. PMID: 30076951 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharm Sci Source Type: research
We presently forget 98% of everything we experience. That will go away in favor of perfect, controllable, configurable memory. Skills and knowledge will become commodities that can be purchased and installed. We will be able to feel exactly as we wish to feel at any given time. How we perceive the world will be mutable and subject to choice. How we think, the very fundamental basis of the mind, will also be mutable and subject to choice. We will merge with our machines, as Kurzweil puts it. The boundary between mind and computing device, between the individual and his or her tools, will blur. Over the course of the ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: In conclusion, the current study showed that rosmarinic acid induced potent anticancer effects in OCVAR- 3 cancer cells by inducing apoptosis, inhibiting cell migration and modulating lncRNA Malat-1 expression. PMID: 30003749 [PubMed - in process]
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
The glycoprotein CD56, also known as a neural cell adhesion molecule (NCAM), plays an important role in normal physiological functions.   It is expressed in low levels in normal cells such as neurons, glia, skeletal muscle and natural killer cells. It is highly expressed on a variety of cancerous cells including those of neuroblastoma, small-cell lung cancer, and multiple myeloma.  In neuroblastoma, patients undergo a very aggress ive standard of care regimen that results in a high mortality rate.  Many neuroblastomas have increased expression of CD56, which represents a possible therapeutic target for these...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
ConclusionBinimetinib may present a new treatment option for hormone- and chemotherapy-resistant LGSOC harboring KRAS mutations.
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Publication date: May 2018Source: Gynecologic Oncology Reports, Volume 24Author(s): Kayo Inoue, Hiroshi Tsubamoto, Keiko Ishida-Nisigami, Yoshitaka Torii, Seiichi HirotaAbstractOvarian Sertoli cell tumors (SCTs) are rare sex cord tumors (Oliva et al., 2005). The standard treatment for high-grade SCTs is surgery followed by platinum-based chemotherapy. Although platinum-based chemotherapy is also an option for recurrent SCTs (Sigismondi et al., 2012), there is no established chemotherapy regimen for platinum-resistant recurrent SCTs. The effectiveness of pazopanib in treating epithelial ovarian cancer has recently been repo...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Publication date: Available online 31 March 2017Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Patrick Eulitt, Denise Fabian, Crystal Kelly, Jessica Hemminger, Basem M. WilliamAbstractWaldenström’s macroglobulinemia is a rare hematology malignancy which often presents with “B symptoms,” anemia, and thrombocytopenia. A 46-year-old woman presented with 2 months of abdominal distension accompanied by an unintentional 20-lb weight loss. Her abdominal CT scan demonstrated diffuse carcinomatosis with bilateral ovarian lesions and screening labs revealed a markedly elevated CA-125, suggesting a...
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research
AbstractPurposeMalignant cells exhibit increased rates of aerobic glycolysis. Here, we tested whether the accumulation of fluoro-deoxyglucose-6-phosphate (FDG6P) in ovarian cancers of differential malignancy reflects inversely correlated elevations of hexokinase (HK) and glucose-6-phosphatase (G6Pase) activities.ProceduresTwenty-nine women with suspected ovarian cancer had positron emission tomography (PET) prior to surgery. From fresh-frozen tissue, we determined the activities of HK and G6Pase, and from the PET images, we determined the tumor maximum standardized uptake value (SUVmax) of 2-deoxy-2-[18F]fluoro-D-glucose.R...
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionBinimetinib may present a new treatment option for hormone- and chemotherapy-resistant LGSOC harboring KRAS mutations.
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
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