A supplementary functional connectivity microstate attached to the default mode network in depression revealed by resting-state magnetoencephalography

Publication date: 20 April 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 83 Author(s): Siqi Zhang, Shui Tian, Mohammad Ridwan Chattun, Hao Tang, Rui Yan, Kun Bi, Zhijian Yao, Qing Lu Default mode network (DMN) has discernable involvement in the representation of negative, self-referential information in depression. Both increased and decreased resting-state functional connectivity between the anterior and posterior DMN have been observed in depression. These conflicting connectivity differences necessitated further exploration of the resting-state DMN dysfunction in depression. Hence, we investigated the time-varying dynamic interactions within the DMN via functional connectivity microstates in a sub-second level. 25 patients with depression and 25 matched healthy controls were enrolled in the MEG analysis. Spherical K-means algorithms embedded within an iterative optimization frame were applied to sliding windowed correlation matrices, resulting in sub-second alternations of two functional connectivity microstates for groups and highlighting the presence of functional variability. In the power dominant state, depressed patients showed a transient decreased pattern that reflected inter/intra-subnetwork deregulation. A supplementary negatively correlated state simultaneously presented with increased connectivity between the ventromedial prefrontal cortex (vmPFC) and the posterior cingulate cortex (PCC), two core nodes for the ante...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research