Zn-based porous coordination solid as diclofenac sodium carrier

Publication date: April 2018 Source:Journal of Solid State Chemistry, Volume 260 Author(s): Guilherme Nunes Lucena, Renata Carolina Alves, Marina Paiva Abuçafy, Leila Aparecida Chiavacci, Isabel Cristiane da Silva, Fernando Rogério Pavan, Regina Célia Galvão Frem Drug delivery systems produced with biocompatible components can be used to reduce adverse effects and improve therapy efficacy. Most of the carrier materials reported in the literature show poor drug loading and rapid release. However, porous hybrid solids, such as metal-organic frameworks, are well suited to serve as carriers for delivery and imaging applications. In this work, a luminescent and nontoxic porous Zn(II) coordination polymer with 4,4′-biphenyl-dicarboxylic acid (BPDC) and adenine linkers (BioMOF-Zn) was synthesized by a solvothermal process and characterized by PXRD, TGA, SEM-FEG, and FTIR. Nitrogen adsorption measurements revealed the presence of micropores as well as mesopores in the framework after activation of the material. The blue-emitting BioMOF-Zn exhibited an outstanding loading capacity (1.72gg−1) and satisfactory release capability (56% after two days) for diclofenac sodium. Graphical abstract
Source: Journal of Solid State Chemistry - Category: Chemistry Source Type: research