Differential diagnostic perspectives provided by en face microscopic examination of articular surface defects

AbstractSurface defects have a central position in diagnosis of articular pathology. Recognizing the limitations of standard radiologic techniques and those imposed by positioning and averaging artifacts on CT evaluation, direct visualization of surface defects was pursued to identify disease characteristics that would facilitate interpretation of radiologic findings. Epi-illumination surface microscopy was utilized to examine macroscopically recognized articular surface defects in individuals in the Hamann-Todd, Terry, and Huntington human skeletal collections with previously verified diagnoses of rheumatoid arthritis, spondyloarthropathy, juvenile inflammatory arthritis (JIA), calcium pyrophosphate deposition disease (CPPD), gout, metastatic cancer, multiple myeloma, septic arthritis, tuberculosis, fungal arthritis, histiocytosis and sickle cell anemia (Rothschild and Rothschild Clin Infect Dis 20(5):1402 –1408,1995; Rothschild et al. Amer J Phys Anthropol 82(4):441 –449,1990; Rothschild and Rothschild Amer J Phys Anthropol 96(4):357 –563,1995; Rothschild and Woods Clin Exp Rheumatol 10(2):117 –122,1992; Barrett and Keat Radiographics 24(6):1679 –1691,2004; Rothschild and Heathcote Amer J Phys Anthropol 98(4):519 –525,1995; Rothschild and Woods Am J Phys Anthropol 85:25 –34,1991; Hershkovitz et al. Amer J Phys Anthropol 106(1):47 –60,1998; Winland et al. Amer J Phys Anthropol 24:S243,1997; Rothschild et al. Clin Exp Rheumatol 10(6):557 –564,1992; Rothschil...

Source: Clinical Rheumatology - February 4, 2018 Category: Rheumatology Source Type: research