Inflammation-Associated Cytokines IGFBP1 and RANTES Impair the Megakaryocytic Potential of HSCs in PT Patients after Allo-HSCT

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a pivotal therapy for an increasing variety of malignant and non-malignant hematologic disorders[1]. Platelet reconstitution is a key measurement of successful engraftment after HSCT. However, prolonged isolated thrombocytopenia (PT), a frequent complication in patients after allo-HSCT, occurs in 5 –37% of HSCT recipients[3,4,5] . The diagnosis of PT is made when a decrease in platelet number (

Source: Biology of Blood and Marrow Transplantation - February 3, 2018 Category: Hematology Authors: Cuicui Liu, Yiqing Yang, Dan Wu, Wenxia Zhang, Hongtao Wang, Pei Su, Jianfeng Yao, Chen Liang, Sizhou Feng, Mingzhe Han, Fuxu Wang, Erlie Jiang, Jiaxi Zhou Source Type: research