Biomarkers of Alzheimers Disease in Down Syndrome (R01)

Funding Opportunity RFA-AG-15-011 from the NIH Guide for Grants and Contracts. The goal of this funding opportunity announcement is to enable the identification of the longitudinal progression of Alzheimer's disease in adults with Down Syndrome using clinical, cognitive, imaging, genetic and biochemical biomarkers.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

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Authors: Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC Abstract OBJECTIVE: Recent clinical trials targeting amyloid beta (Aβ) and tau in Alzheimer's disease (AD) have yet to demonstrate efficacy. Reviewing the hypotheses for AD pathogenesis and defining possible links between them may enhance insights into both upstream initiating events and downstream mechanisms, thereby promoting discovery of novel treatments. Evidence that in Down syndrome (DS), a population markedly predisposed to develop early onset AD, increased APP gene dose is necessary for both AD neuropat...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
PET imaging could be a useful tool for diagnosis and treatment of idiopathic...Read more on AuntMinnie.comRelated Reading: FDG levels show link between Alzheimer's, Down syndrome SNMMI 2020: Image of the Year scans reveal 'super-agers' New tau PET tracer better targets source of Alzheimer's New PET technique visualizes early Alzheimer's disease PET tracer could more precisely diagnose Alzheimer's
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
The U.S. National Institutes of Health (NIH) has provided additional funding...Read more on AuntMinnie.comRelated Reading: MRI-trained CAD identifies cognitive impairment FDG levels show link between Alzheimer's, Down syndrome New tau PET tracer better targets source of Alzheimer's New PET technique visualizes early Alzheimer's disease PET tracer could more precisely diagnose Alzheimer's
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Abstract Classical views of hereditary mechanisms consider linear nucleic acids, DNA and RNA, as template molecules wherein genetic information is encoded by the sequence of nitrogenous bases. The template principle embodied in the central dogma of molecular biology describes the allowed paths of genetic information transfer from nucleic acids to proteins. The discovery of prions revealed an additional hereditary mechanism whereby the spatial structure is transmitted from one protein molecule to another independently of the sequence of nitrogenous bases in their structural genes. The simultaneous existence of line...
Source: Molekuliarnaia Biologiia - Category: Molecular Biology Authors: Tags: Mol Biol (Mosk) Source Type: research
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit. Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Alzheimer ’s disease (AD) is the major cause of death in adults with Down syndrome (DS). There is an urgent need for objective markers of AD in the DS population to improve early diagnosis and monitor disease p...
Source: Molecular Neurodegeneration - Category: Neurology Authors: Tags: Research article Source Type: research
Publication date: Available online 11 August 2020Source: Progress in NeurobiologyAuthor(s): Chiara Lanzillotta, Ilaria Zuliani, Antonella Tramutola, Eugenio Barone, Carla Blarzino, Valentina Folgiero, Matteo Caforio, Diletta Valentini, Alberto Villani, Franco Locatelli, D. Allan Butterfield, Elizabeth Head, Marzia Perluigi, Jose F. Abisambra, Fabio Di Domenico
Source: Progress in Neurobiology - Category: Neuroscience Source Type: research
PET imaging has revealed reduced FDG uptake in key brain regions associated...Read more on AuntMinnie.comRelated Reading: PET, MRI uncover women's predisposition to Alzheimer's New tau PET tracer better targets source of Alzheimer's PET links lower sleep levels with Alzheimer's risk New PET technique visualizes early Alzheimer's disease PET tracer could more precisely diagnose Alzheimer's
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Researchers Detangle Protein Interaction Implicated in Down Syndrome and Alzheimer's New findings by chemists Wolfgang Peti and Rebecca Page provide a foundation to better understand and treat these neurological disorders. Brittany Uhlorn Today BIO5 InstituteNMR_room_PC Wolfgang Peti-web.jpg The powerful biomolecular NMR spectrometers at the University of Arizona have allowed scientists to gain molecular details of the interaction between RCAN1 and calcineurin, two proteins that have long been implicated in Down syndrome and Alzheimer's disease.HealthScience and TechnologyBIO5College of ScienceMedia contact...
Source: The University of Arizona: Health - Category: Universities & Medical Training Authors: Source Type: research
e;cher J, Varea E Abstract The piriform cortex is involved in olfactory information processing, that is altered in Down Syndrome. Moreover, piriform cortex has a crucial involvement in epilepsy generation and is one of the first regions affected in Alzheimer's Disease, both maladies being prevalent among Down Syndrome individuals. In this work, we studied the alterations in neuronal morphology, synaptology and structural plasticity in the piriform cortex of the Ts65Dn mouse model, which is the most used model for the study of this syndrome and mimics some of their alterations. We have observed that Ts65Dn piriform...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
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