Altered auditory processing and effective connectivity in 22q11.2 deletion syndrome

22q11.2 deletion syndrome (22q11.2DS) is one of the most common copy number variants and confers a markedly increased risk for schizophrenia. As such, 22q11.2DS is a homogeneous genetic liability model which enables studies to delineate functional abnormalities that may precede disease onset. Mismatch negativity (MMN), a brain marker of change detection, is reduced in people with schizophrenia compared to healthy controls. Using dynamic causal modelling (DCM), previous studies showed that top-down effective connectivity linking the frontal and temporal cortex is reduced in schizophrenia relative to healthy controls in MMN tasks.

Source: Schizophrenia Research - February 3, 2018 Category: Psychiatry Authors: Kit Melissa Larsen, Morten M ørup, Michelle Rosgaard Birknow, Elvira Fischer, Oliver Hulme, Anders Vangkilde, Henriette Schmock, William Frans Christiaan Baaré, Michael Didriksen, Line Olsen, Thomas Werge, Hartwig R. Siebner, Marta I. Garrido Source Type: research